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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0027895,
umls-concept:C0037083,
umls-concept:C0040648,
umls-concept:C0279266,
umls-concept:C0439784,
umls-concept:C0805701,
umls-concept:C1158478,
umls-concept:C1705422,
umls-concept:C1710082,
umls-concept:C2003939,
umls-concept:C2348235
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pubmed:issue |
1
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pubmed:dateCreated |
2003-4-7
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pubmed:abstractText |
Individual neurons express only one or a few of the many identified neurotransmitters and neuropeptides, but the molecular mechanisms controlling their selection are poorly understood. In the Drosophila ventral nerve cord, the six Tv neurons express the neuropeptide gene FMRFamide. Each Tv neuron resides within a neuronal cell group specified by the LIM-homeodomain gene apterous. We find that the zinc-finger gene squeeze acts in Tv cells to promote their unique axon pathfinding to a peripheral target. There, the BMP ligand Glass bottom boat activates the Wishful thinking receptor, initiating a retrograde BMP signal in the Tv neuron. This signal acts together with apterous and squeeze to activate FMRFamide expression. Reconstituting this "code," by combined BMP activation and apterous/squeeze misexpression, triggers ectopic FMRFamide expression in peptidergic neurons. Thus, an intrinsic transcription factor code integrates with an extrinsic retrograde signal to select a specific neuropeptide identity within peptidergic cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/FMRFamide,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/LIM-Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/ap protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/gbb protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/wit protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
4
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pubmed:volume |
113
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
73-86
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:12679036-Animals,
pubmed-meshheading:12679036-Body Patterning,
pubmed-meshheading:12679036-Bone Morphogenetic Proteins,
pubmed-meshheading:12679036-Cell Communication,
pubmed-meshheading:12679036-Cell Differentiation,
pubmed-meshheading:12679036-Central Nervous System,
pubmed-meshheading:12679036-Choristoma,
pubmed-meshheading:12679036-Drosophila Proteins,
pubmed-meshheading:12679036-Drosophila melanogaster,
pubmed-meshheading:12679036-FMRFamide,
pubmed-meshheading:12679036-Ganglia, Invertebrate,
pubmed-meshheading:12679036-Gene Expression Regulation, Developmental,
pubmed-meshheading:12679036-Growth Cones,
pubmed-meshheading:12679036-Homeodomain Proteins,
pubmed-meshheading:12679036-LIM-Homeodomain Proteins,
pubmed-meshheading:12679036-Mutation,
pubmed-meshheading:12679036-Neurons,
pubmed-meshheading:12679036-Receptors, Cell Surface,
pubmed-meshheading:12679036-Signal Transduction,
pubmed-meshheading:12679036-Transcription Factors,
pubmed-meshheading:12679036-Transforming Growth Factor beta,
pubmed-meshheading:12679036-Zinc Fingers
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pubmed:year |
2003
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pubmed:articleTitle |
Specification of neuropeptide cell identity by the integration of retrograde BMP signaling and a combinatorial transcription factor code.
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pubmed:affiliation |
Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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