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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2003-4-4
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pubmed:abstractText |
Renal failure has been viewed as a state of cellular calcium toxicity due to the retention of small fast-acting molecules. We have tested this hypothesis and identified potentially neuroexcitatory compounds among a number of putative uremic neurotoxins by examining the acute in vitro effects of these compounds on cultured central neurons. The in vitro neuroexcitatory and synergistic effects of guanidinosuccinate and spermine were also examined in vivo.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-Amino-5-phosphonovalerate,
http://linkedlifedata.com/resource/pubmed/chemical/2-amino-4-methyl-5-phosphono-3-pente...,
http://linkedlifedata.com/resource/pubmed/chemical/6-Cyano-7-nitroquinoxaline-2,3-dione,
http://linkedlifedata.com/resource/pubmed/chemical/Bicuculline,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/GABA Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Guanidines,
http://linkedlifedata.com/resource/pubmed/chemical/Nickel,
http://linkedlifedata.com/resource/pubmed/chemical/Piperidines,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channel Blockers,
http://linkedlifedata.com/resource/pubmed/chemical/Spermine,
http://linkedlifedata.com/resource/pubmed/chemical/Succinates,
http://linkedlifedata.com/resource/pubmed/chemical/Tetraethylammonium,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrodotoxin,
http://linkedlifedata.com/resource/pubmed/chemical/guanidinosuccinic acid,
http://linkedlifedata.com/resource/pubmed/chemical/ifenprodil
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0085-2538
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1764-75
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12675852-2-Amino-5-phosphonovalerate,
pubmed-meshheading:12675852-6-Cyano-7-nitroquinoxaline-2,3-dione,
pubmed-meshheading:12675852-Animals,
pubmed-meshheading:12675852-Bicuculline,
pubmed-meshheading:12675852-Calcium Channels,
pubmed-meshheading:12675852-Cells, Cultured,
pubmed-meshheading:12675852-Drug Synergism,
pubmed-meshheading:12675852-Excitatory Amino Acid Antagonists,
pubmed-meshheading:12675852-GABA Antagonists,
pubmed-meshheading:12675852-Guanidines,
pubmed-meshheading:12675852-Membrane Potentials,
pubmed-meshheading:12675852-Mice,
pubmed-meshheading:12675852-Neurons,
pubmed-meshheading:12675852-Nickel,
pubmed-meshheading:12675852-Piperidines,
pubmed-meshheading:12675852-Potassium Channel Blockers,
pubmed-meshheading:12675852-Seizures,
pubmed-meshheading:12675852-Spermine,
pubmed-meshheading:12675852-Spinal Cord,
pubmed-meshheading:12675852-Succinates,
pubmed-meshheading:12675852-Synapses,
pubmed-meshheading:12675852-Tetraethylammonium,
pubmed-meshheading:12675852-Tetrodotoxin,
pubmed-meshheading:12675852-Uremia
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pubmed:year |
2003
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pubmed:articleTitle |
Involvement of voltage- and ligand-gated Ca2+ channels in the neuroexcitatory and synergistic effects of putative uremic neurotoxins.
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pubmed:affiliation |
Laboratory of Neurochemistry and Behavior and Laboratory of Electrobiology, Born-Bunge Foundation, University of Antwerp, Belgium. rdhooge@uia.ac.be
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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