Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2003-4-3
pubmed:abstractText
The extent to which highly active antiretroviral therapy can restore thymic function in HIV-1 infected patients is not known. We simulate treatment using a temporal model of thymopoiesis during HIV-1 infection, tracking thymic function by the number of recent thymic emigrants (RTE) exported to the periphery per day. Our results suggest that suppressing viral load in peripheral blood and improving inherent thymic function are necessary for the reconstitution of RTE levels in adult thymic infection with either R5 or X4 HIV-1 strains. This is also the case in pediatric thymic infection with R5 strains. However, recovery of RTE levels during pediatric infection with X4 strains also depends on high drug efficacy within the thymus. We further predict that protease inhibitors have high levels of efficacy directly suppressing viral replication within the thymus, while reverse transcriptase inhibitors have low efficacy.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1521-6616
pubmed:author
pubmed:issnType
Print
pubmed:volume
106
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
95-105
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:12672400-Adult, pubmed-meshheading:12672400-Algorithms, pubmed-meshheading:12672400-Anti-HIV Agents, pubmed-meshheading:12672400-Antiretroviral Therapy, Highly Active, pubmed-meshheading:12672400-CD4 Lymphocyte Count, pubmed-meshheading:12672400-HIV Infections, pubmed-meshheading:12672400-HIV Protease Inhibitors, pubmed-meshheading:12672400-HIV-1, pubmed-meshheading:12672400-Hematopoiesis, pubmed-meshheading:12672400-Humans, pubmed-meshheading:12672400-Infant, pubmed-meshheading:12672400-Models, Biological, pubmed-meshheading:12672400-Reverse Transcriptase Inhibitors, pubmed-meshheading:12672400-T-Lymphocytes, pubmed-meshheading:12672400-Thymus Gland, pubmed-meshheading:12672400-Viral Load, pubmed-meshheading:12672400-Viremia, pubmed-meshheading:12672400-Virus Replication
pubmed:year
2003
pubmed:articleTitle
Reconstitution of thymic function in HIV-1 patients treated with highly active antiretroviral therapy.
pubmed:affiliation
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't