| pubmed-article:12672049 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12672049 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:12672049 | lifeskim:mentions | umls-concept:C0079488 | lld:lifeskim |
| pubmed-article:12672049 | lifeskim:mentions | umls-concept:C0027950 | lld:lifeskim |
| pubmed-article:12672049 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:12672049 | lifeskim:mentions | umls-concept:C0752312 | lld:lifeskim |
| pubmed-article:12672049 | lifeskim:mentions | umls-concept:C1370600 | lld:lifeskim |
| pubmed-article:12672049 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:12672049 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:12672049 | lifeskim:mentions | umls-concept:C1515877 | lld:lifeskim |
| pubmed-article:12672049 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:12672049 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:12672049 | pubmed:dateCreated | 2003-4-2 | lld:pubmed |
| pubmed-article:12672049 | pubmed:abstractText | Infection by Helicobacter pylori causes an acute inflammatory response followed by a chronic infection of the human gastric mucosa characterized by the infiltration of neutrophils andmononuclear inflammatory cells. The neutrophil-activating protein of Helicobacter pylori (HP-NAP) is a virulence factor that activates neutrophils, monocytes, and mast cells. However, the mechanism by which HP-NAP activates these cells is not fully understood. Here, we show that HP-NAP induces extracellular regulated kinase (ERK) and p38-mitogen-activated protein kinase (MAPK) activation in human neutrophils; c-Jun N-terminal kinase is not activated by HP-NAP. A MAPK/ERK kinase inhibitor and a p38-MAPK inhibitor suppress HP-NAP-mediated neutrophil oxidative burst, adhesion, andchemotaxis, but not actin polymerization. Pertussis toxin (PTX) inhibits all these neutrophil functions and the MAPK activation caused by HP-NAP. These results demonstrate that HP-NAP activates neutrophils through a PTX-sensitive pathway and that ERK and p38-MAPK are involved in many neutrophil functions stimulated by HP-NAP. | lld:pubmed |
| pubmed-article:12672049 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12672049 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12672049 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12672049 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12672049 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12672049 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12672049 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12672049 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12672049 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12672049 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12672049 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12672049 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12672049 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12672049 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12672049 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12672049 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12672049 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:12672049 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:12672049 | pubmed:author | pubmed-author:RappuoliRinoR | lld:pubmed |
| pubmed-article:12672049 | pubmed:author | pubmed-author:MontecuccoCes... | lld:pubmed |
| pubmed-article:12672049 | pubmed:author | pubmed-author:Del... | lld:pubmed |
| pubmed-article:12672049 | pubmed:author | pubmed-author:NishiokaHiroa... | lld:pubmed |
| pubmed-article:12672049 | pubmed:author | pubmed-author:SemenzatoGian... | lld:pubmed |
| pubmed-article:12672049 | pubmed:author | pubmed-author:TrentinLivioL | lld:pubmed |
| pubmed-article:12672049 | pubmed:author | pubmed-author:BaessoIleniaI | lld:pubmed |
| pubmed-article:12672049 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12672049 | pubmed:volume | 33 | lld:pubmed |
| pubmed-article:12672049 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12672049 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12672049 | pubmed:pagination | 840-9 | lld:pubmed |
| pubmed-article:12672049 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:12672049 | pubmed:meshHeading | pubmed-meshheading:12672049... | lld:pubmed |
| pubmed-article:12672049 | pubmed:meshHeading | pubmed-meshheading:12672049... | lld:pubmed |
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| pubmed-article:12672049 | pubmed:meshHeading | pubmed-meshheading:12672049... | lld:pubmed |
| pubmed-article:12672049 | pubmed:meshHeading | pubmed-meshheading:12672049... | lld:pubmed |
| pubmed-article:12672049 | pubmed:meshHeading | pubmed-meshheading:12672049... | lld:pubmed |
| pubmed-article:12672049 | pubmed:meshHeading | pubmed-meshheading:12672049... | lld:pubmed |
| pubmed-article:12672049 | pubmed:meshHeading | pubmed-meshheading:12672049... | lld:pubmed |
| pubmed-article:12672049 | pubmed:meshHeading | pubmed-meshheading:12672049... | lld:pubmed |
| pubmed-article:12672049 | pubmed:meshHeading | pubmed-meshheading:12672049... | lld:pubmed |
| pubmed-article:12672049 | pubmed:meshHeading | pubmed-meshheading:12672049... | lld:pubmed |
| pubmed-article:12672049 | pubmed:meshHeading | pubmed-meshheading:12672049... | lld:pubmed |
| pubmed-article:12672049 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12672049 | pubmed:articleTitle | The neutrophil-activating protein of Helicobacter pylori (HP-NAP) activates the MAPK pathway in human neutrophils. | lld:pubmed |
| pubmed-article:12672049 | pubmed:affiliation | Istituto Veneto di Medicina Molecolare, Immunologia Clinica, Università di Padova, Padova, Italy. hiroaki.nishioka@pathology.oxford.ac.uk | lld:pubmed |
| pubmed-article:12672049 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12672049 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12672049 | lld:pubmed |
