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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2003-3-28
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pubmed:abstractText |
Purine analogs and alkylators are important agents in the treatment of chronic lymphocytic leukemia (CLL). Previously, combinations of fludarabine and chlorambucil were abandoned because of increased toxicity from overlapping myelosuppression and immunosuppression. Of the purine analogs active in CLL, pentostatin may be least myelosuppressive. We hypothesized that combining pentostatin with cyclophosphamide would have less myelotoxicity than combinations using other purine analogs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0732-183X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1278-84
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:12663715-Adult,
pubmed-meshheading:12663715-Aged,
pubmed-meshheading:12663715-Antibiotics, Antineoplastic,
pubmed-meshheading:12663715-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:12663715-Bone Marrow,
pubmed-meshheading:12663715-Cyclophosphamide,
pubmed-meshheading:12663715-Drug Administration Schedule,
pubmed-meshheading:12663715-Drug Resistance,
pubmed-meshheading:12663715-Female,
pubmed-meshheading:12663715-Humans,
pubmed-meshheading:12663715-Immunosuppressive Agents,
pubmed-meshheading:12663715-Leukemia, Lymphocytic, Chronic, B-Cell,
pubmed-meshheading:12663715-Male,
pubmed-meshheading:12663715-Middle Aged,
pubmed-meshheading:12663715-Neutropenia,
pubmed-meshheading:12663715-Pentostatin,
pubmed-meshheading:12663715-Thrombocytopenia,
pubmed-meshheading:12663715-Treatment Outcome,
pubmed-meshheading:12663715-Vidarabine
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pubmed:year |
2003
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pubmed:articleTitle |
Pentostatin and cyclophosphamide: an effective new regimen in previously treated patients with chronic lymphocytic leukemia.
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pubmed:affiliation |
Leukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, and Cornell University Medical College, New York, NY 10021, USA. weissm@mskcc.org
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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