Linked Life Data

12655509

Source:http://linkedlifedata.com/resource/pubmed/id/12655509

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2003-3-25
pubmed:abstractText
Extracellular ATP is a signaling molecule, working through P2X purinoceptors in the nervous system. P2X7 is a major subtype of the purinoceptors in the brain, where it is expressed mostly in glia cells and considered to work as a trigger of cytolysis. In the rodent retina, however, P2X7 is expressed in several classes of neurons including ganglion cells. In the present study we identified cells immunopositive for P2X7 by double immunolabeling. Immunoreactivity for P2X7 was observed in the inner nuclear layer (INL), the inner plexiform layer (IPL), and the ganglion cell layer (GCL). In the INL, strongly immunopositive cells corresponded to the subpopulation of horizontal cells. In the IPL, fine processes were immunopositive. In the GCL, most of the ganglion cells showed P2X7 immunoreactivity. At the ultrastructural level, immunoreactivity was confirmed in the cytoplasm of ganglion cells. No P2X7 immunoreactivity was found in non-neural cells, i.e., Müller cells or microglia. The immunohistochemical distribution of other purinoceptor subtypes (P2X1, P2X2, and P2X4) was also examined in the monkey retina. Immunoreactivity for P2X1 was strongly detected in a band, in sublamina a of the IPL. The band existed at almost the same level as tyrosine hydroxylase immunoreactivity, but did not seem to actually overlap. P2X2 was not expressed in the retina, and P2X4 was only faintly expressed at the scleral margin of the INL. Because P2X7 in the primate retina is expressed exclusively in neurons, it may in this location be involved in neural transmission rather than in cytolysis, as found for glia cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0021-9967
pubmed:author
pubmed:copyrightInfo
Copyright 2003 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:day
5
pubmed:volume
459
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
267-77
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Neuron-specific distribution of P2X7 purinergic receptors in the monkey retina.
pubmed:affiliation
Laboratory for Neural Architecture, Brain Science Institute (BSI), RIKEN, Wako, Saitama 351-0198, Japan. kishii@brain.riken.go.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't