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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2003-3-25
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pubmed:abstractText |
The clinical benefits of statins are attributed to changes in plaque composition that lead to reduced metalloproteinase (MMP) activity and plaque stabilization. However, the molecular mechanism of this effect is unclear. Recently, we demonstrated enhanced expression of isoforms of inducible cyclooxygenase (COX) and PGE synthase (COX-2/mPGES) in human symptomatic plaque and provided evidence that this is associated with MMP-induced plaque rupture. The aim of this study was to characterize the effect of simvastatin on inflammatory infiltration and the expression of COX-2/mPGES and MMPs in human carotid plaques.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2 Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxymethylglutaryl-CoA...,
http://linkedlifedata.com/resource/pubmed/chemical/Intramolecular Oxidoreductases,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinases,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PTGS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases,
http://linkedlifedata.com/resource/pubmed/chemical/Simvastatin,
http://linkedlifedata.com/resource/pubmed/chemical/prostaglandin-E synthase
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1524-4539
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pubmed:author |
pubmed-author:ArteseLucianoL,
pubmed-author:BajocchiGuidoG,
pubmed-author:BeiRobertoR,
pubmed-author:ChiarelliFrancescoF,
pubmed-author:CipolloneFrancescoF,
pubmed-author:CuccurulloFrancoF,
pubmed-author:De CesareDomenicoD,
pubmed-author:FaziaMariaM,
pubmed-author:IezziAnnalisaA,
pubmed-author:MezzettiAndreaA,
pubmed-author:MuraroRaffaellaR,
pubmed-author:PiattelliAdrianoA,
pubmed-author:PiniBarbaraB,
pubmed-author:SpigonardoFrancescoF,
pubmed-author:UcchinoSanteS,
pubmed-author:ZucchelliMircoM
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pubmed:issnType |
Electronic
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pubmed:day |
25
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pubmed:volume |
107
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1479-85
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12654603-Aged,
pubmed-meshheading:12654603-Carotid Stenosis,
pubmed-meshheading:12654603-Cell Movement,
pubmed-meshheading:12654603-Cells, Cultured,
pubmed-meshheading:12654603-Combined Modality Therapy,
pubmed-meshheading:12654603-Cyclooxygenase 2,
pubmed-meshheading:12654603-Cyclooxygenase 2 Inhibitors,
pubmed-meshheading:12654603-Cyclooxygenase Inhibitors,
pubmed-meshheading:12654603-Dinoprostone,
pubmed-meshheading:12654603-Enzyme Inhibitors,
pubmed-meshheading:12654603-Extracellular Matrix,
pubmed-meshheading:12654603-Female,
pubmed-meshheading:12654603-Humans,
pubmed-meshheading:12654603-Hydroxymethylglutaryl-CoA Reductase Inhibitors,
pubmed-meshheading:12654603-Inflammation,
pubmed-meshheading:12654603-Intramolecular Oxidoreductases,
pubmed-meshheading:12654603-Isoenzymes,
pubmed-meshheading:12654603-Macrophage Activation,
pubmed-meshheading:12654603-Macrophages,
pubmed-meshheading:12654603-Male,
pubmed-meshheading:12654603-Matrix Metalloproteinases,
pubmed-meshheading:12654603-Membrane Proteins,
pubmed-meshheading:12654603-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:12654603-Simvastatin,
pubmed-meshheading:12654603-T-Lymphocytes
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pubmed:year |
2003
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pubmed:articleTitle |
Suppression of the functionally coupled cyclooxygenase-2/prostaglandin E synthase as a basis of simvastatin-dependent plaque stabilization in humans.
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pubmed:affiliation |
Department of Medicine and Aging, School of Medicine, University of Chieti G. d'Annunzio, Chieti, Italy.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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