Source:http://linkedlifedata.com/resource/pubmed/id/12654472
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
2003-3-25
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| pubmed:abstractText |
(-)-epicatechin is one of the most potent antioxidants present in the human diet. Particularly high levels are found in black tea, apples, and chocolate. High intake of catechins has been associated with reduced risk of cardiovascular diseases. There have been several reports concerning the bioavailability of catechins, however, the chemical structure of (-)-epicatechin metabolites in blood, tissues, and urine remains unclear. In the present study, we purified and elucidated the chemical structure of (-)-epicatechin metabolites in human and rat urine after oral administration. Three metabolites were purified from human urine including (-)-epicatechin-3'-O-glucuronide, 4'-O-methyl-(-)-epicatechin-3'-O-glucuronide, and 4'-O-methyl-(-)-epicatechin-5 or 7-O-glucuronide, according to 1H- and 13C-NMR, HMBC, and LC-MS analyses. The metabolites purified from rat urine were 3'-O-methyl-(-)-epicatechin, (-)-epicatechin-7-O-glucuronide, and 3'-O-methyl-(-)-epicatechin-7-O-glucuronide. These compounds were also detected in the blood of humans and rats by LC-MS. The presence of these metabolites in blood and urine suggests that catechins are metabolized and circulated in the body after administration of catechin-containing foods.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
0891-5849
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
1
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| pubmed:volume |
34
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
840-9
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12654472-Administration, Oral,
pubmed-meshheading:12654472-Adult,
pubmed-meshheading:12654472-Animals,
pubmed-meshheading:12654472-Catechin,
pubmed-meshheading:12654472-Chromatography, High Pressure Liquid,
pubmed-meshheading:12654472-Female,
pubmed-meshheading:12654472-Free Radicals,
pubmed-meshheading:12654472-Gas Chromatography-Mass Spectrometry,
pubmed-meshheading:12654472-Glucuronic Acid,
pubmed-meshheading:12654472-Glucuronic Acids,
pubmed-meshheading:12654472-Humans,
pubmed-meshheading:12654472-Magnetic Resonance Spectroscopy,
pubmed-meshheading:12654472-Male,
pubmed-meshheading:12654472-Models, Chemical,
pubmed-meshheading:12654472-Rats,
pubmed-meshheading:12654472-Rats, Sprague-Dawley,
pubmed-meshheading:12654472-Species Specificity,
pubmed-meshheading:12654472-Time Factors
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| pubmed:year |
2003
|
| pubmed:articleTitle |
Structures of (-)-epicatechin glucuronide identified from plasma and urine after oral ingestion of (-)-epicatechin: differences between human and rat.
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| pubmed:affiliation |
Health and Bioscience Laboratories, Meiji Seika Kaisha Ltd, Saitama, Japan. midori_natsume@meiji.co.jp
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| pubmed:publicationType |
Journal Article
|