Source:http://linkedlifedata.com/resource/pubmed/id/12649138
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2003-7-1
|
| pubmed:databankReference | |
| pubmed:abstractText |
Insect peptidoglycan recognition protein-S (PGRP-S), a member of a family of innate immunity pattern recognition molecules conserved from insects to mammals, recognizes bacterial cell wall peptidoglycan and activates 2 antimicrobial defense systems, prophenoloxidase cascade and antimicrobial peptides through Toll receptor. We show that mouse PGRP-S is present in neutrophil tertiary granules and that PGRP-S-deficient (PGRP-S-/-) mice have increased susceptibility to intraperitoneal infection with gram-positive bacteria of low pathogenicity but not with more pathogenic gram-positive or gram-negative bacteria. PGRP-S-/- mice have normal inflammatory responses and production of tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6). Neutrophils from PGRP-S-/- mice have normal phagocytic uptake of bacteria but are defective in intracellular killing and digestion of relatively nonpathogenic gram-positive bacteria. Therefore, mammalian PGRP-S functions in intracellular killing of bacteria. Thus, only bacterial recognition by PGRP-S, but not its effector function, is conserved from insects to mammals.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0006-4971
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
102
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
689-97
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:12649138-Animals,
pubmed-meshheading:12649138-Bacteremia,
pubmed-meshheading:12649138-Base Sequence,
pubmed-meshheading:12649138-Carrier Proteins,
pubmed-meshheading:12649138-Chimera,
pubmed-meshheading:12649138-Cytoplasmic Granules,
pubmed-meshheading:12649138-Evolution, Molecular,
pubmed-meshheading:12649138-Female,
pubmed-meshheading:12649138-Genetic Predisposition to Disease,
pubmed-meshheading:12649138-Gram-Negative Bacterial Infections,
pubmed-meshheading:12649138-Gram-Positive Bacterial Infections,
pubmed-meshheading:12649138-Interleukin-6,
pubmed-meshheading:12649138-Male,
pubmed-meshheading:12649138-Mice,
pubmed-meshheading:12649138-Mice, Inbred C57BL,
pubmed-meshheading:12649138-Mice, Inbred ICR,
pubmed-meshheading:12649138-Mice, Knockout,
pubmed-meshheading:12649138-Molecular Sequence Data,
pubmed-meshheading:12649138-Neutrophils,
pubmed-meshheading:12649138-Peritonitis,
pubmed-meshheading:12649138-Phagocytosis,
pubmed-meshheading:12649138-Species Specificity,
pubmed-meshheading:12649138-Tumor Necrosis Factor-alpha
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Defect in neutrophil killing and increased susceptibility to infection with nonpathogenic gram-positive bacteria in peptidoglycan recognition protein-S (PGRP-S)-deficient mice.
|
| pubmed:affiliation |
Northwest Center for Medical Education, Indiana University School of Medicine, 3400 Broadway, Gary, IN 46408, USA. rdziar@iun.edu
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
|