Source:http://linkedlifedata.com/resource/pubmed/id/12643915
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2003-3-19
|
| pubmed:abstractText |
Three novel 4-deacetoxy-1,7-dideoxy azetidine paclitaxel analogues were synthesized through a convenient route that employed hydroboration-amination and intramolecular S(N)2-type substitution reaction from a natural taxoid taxinine. All analogues have been tested for cytotoxicity against three human tumor cell lines. None of them showed remarkable cytotoxicity compared to paclitaxel against tested tumor cell lines.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
24
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1075-7
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:12643915-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:12643915-Azetidines,
pubmed-meshheading:12643915-Drug Screening Assays, Antitumor,
pubmed-meshheading:12643915-Humans,
pubmed-meshheading:12643915-Indicators and Reagents,
pubmed-meshheading:12643915-Paclitaxel,
pubmed-meshheading:12643915-Structure-Activity Relationship,
pubmed-meshheading:12643915-Tumor Cells, Cultured
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Synthesis and biological evaluation of 4-deacetoxy-1,7-dideoxy azetidine paclitaxel analogues.
|
| pubmed:affiliation |
Laboratory of Applied Bioorganic Chemistry, Division of Life Science, Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amamiyamachi, Aoba-ku, Sendai 981-8555, Japan.
|
| pubmed:publicationType |
Journal Article
|