Source:http://linkedlifedata.com/resource/pubmed/id/12639727
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
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pubmed:dateCreated |
2003-3-17
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pubmed:abstractText |
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease involving motor neurons. In addition to motor neuron signs and symptoms, a lack of bedsores has been considered a feature of ALS. Recently, we revealed that galectin-1 is a component of the axonal spheroid, which is an early pathological change of the spinal cord in ALS. To investigate whether galectin-1 is associated with skin changes in ALS, we performed an immunohistochemical investigation using anti-galectin-1 antibodies. The present study revealed that galectin-1 immunoreactivity is reduced in the skin of patients with ALS, suggesting that cutaneous galectin-1 is involved in the pathological process of ALS.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-510X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
208
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
67-70
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12639727-Aged,
pubmed-meshheading:12639727-Amyotrophic Lateral Sclerosis,
pubmed-meshheading:12639727-Biopsy,
pubmed-meshheading:12639727-Blotting, Western,
pubmed-meshheading:12639727-Female,
pubmed-meshheading:12639727-Galectin 1,
pubmed-meshheading:12639727-Humans,
pubmed-meshheading:12639727-Immunohistochemistry,
pubmed-meshheading:12639727-Male,
pubmed-meshheading:12639727-Middle Aged,
pubmed-meshheading:12639727-Skin
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pubmed:year |
2003
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pubmed:articleTitle |
Decreased galectin-1 immunoreactivity of the skin in amyotrophic lateral sclerosis.
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pubmed:affiliation |
Third Department of Internal Medicine, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Japan. mwada@yacht.ocn.ne.jp
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pubmed:publicationType |
Journal Article,
Comparative Study
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