Source:http://linkedlifedata.com/resource/pubmed/id/12639558
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2003-3-17
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pubmed:abstractText |
A new cancer cell growth inhibitory (P388 lymphocytic leukemia ED(50) 2.8 microg/mL) cyclodecapeptide designated phakellistatin 12 (2) has been isolated as a trace (1.7 x 10(-6)% yield) constituent of the Western Pacific Ocean (Federated States of Micronesia-Chuuk) sponge Phakellia sp. Employing principally a combination of high resolution FAB with high field (500 MHz) 1H, 13C and 2-D NMR and chiral GC analyses the structure (all S chirality) cyclo-Ile-Phe-Thr-Leu-Pro-Pro-Tyr-Ile-Pro-Pro was assigned.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0960-894X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
685-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12639558-Animals,
pubmed-meshheading:12639558-Antineoplastic Agents,
pubmed-meshheading:12639558-Chromatography, Gas,
pubmed-meshheading:12639558-Magnetic Resonance Spectroscopy,
pubmed-meshheading:12639558-Molecular Structure,
pubmed-meshheading:12639558-Peptides, Cyclic,
pubmed-meshheading:12639558-Porifera,
pubmed-meshheading:12639558-Spectrometry, Mass, Fast Atom Bombardment,
pubmed-meshheading:12639558-Stereoisomerism
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pubmed:year |
2003
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pubmed:articleTitle |
Antineoplastic agents 390. Isolation and structure of phakellistatin 12 from a Chuuk archipelago marine sponge.
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pubmed:affiliation |
Cancer Research Institute, Arizona State University, PO Box 872404, Tempe, AZ 85287-2404, USA. bpettit@asu.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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