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rdf:type |
|
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lifeskim:mentions |
umls-concept:C0014994,
umls-concept:C0205177,
umls-concept:C0205531,
umls-concept:C0216660,
umls-concept:C0220781,
umls-concept:C0220825,
umls-concept:C0226896,
umls-concept:C0243072,
umls-concept:C0439849,
umls-concept:C0442027,
umls-concept:C0445223,
umls-concept:C1527415,
umls-concept:C1552599,
umls-concept:C1704787,
umls-concept:C1883254
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|
pubmed:issue |
4
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|
pubmed:dateCreated |
2003-3-17
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|
pubmed:abstractText |
We synthesized bicyclic ether sialidase inhibitors such as tetrahydro-furan-2-yl, tetrahydro-pyran-2-yl, and oxepan-2-yl derivatives related to zanamivir. These compounds substituted by diol at the C-3' and C-4' positions resulted in the retention of low nanomolar inhibitory activities against not only influenza A virus sialidase but also influenza A virus in cell culture. Compound 11a in particular showed comparable efficacy in vivo relative to that of oseltamivir phosphate.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0960-894X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
13
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
669-73
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12639555-Administration, Oral,
pubmed-meshheading:12639555-Animals,
pubmed-meshheading:12639555-Antiviral Agents,
pubmed-meshheading:12639555-Bicyclo Compounds, Heterocyclic,
pubmed-meshheading:12639555-Drug Evaluation, Preclinical,
pubmed-meshheading:12639555-Enzyme Inhibitors,
pubmed-meshheading:12639555-Ethers,
pubmed-meshheading:12639555-Guanidines,
pubmed-meshheading:12639555-Influenza A virus,
pubmed-meshheading:12639555-Inhibitory Concentration 50,
pubmed-meshheading:12639555-Mice,
pubmed-meshheading:12639555-Models, Molecular,
pubmed-meshheading:12639555-Molecular Conformation,
pubmed-meshheading:12639555-Neuraminidase,
pubmed-meshheading:12639555-Orthomyxoviridae Infections,
pubmed-meshheading:12639555-Pyrans,
pubmed-meshheading:12639555-Sialic Acids,
pubmed-meshheading:12639555-Structure-Activity Relationship,
pubmed-meshheading:12639555-Zanamivir
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|
pubmed:year |
2003
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pubmed:articleTitle |
Synthesis and anti-influenza evaluation of orally active bicyclic ether derivatives related to zanamivir.
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pubmed:affiliation |
Medicinal Chemistry Research Laboratories, Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.
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pubmed:publicationType |
Journal Article
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