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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2003-3-17
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pubmed:abstractText |
We have synthesised a series of 2-[[2-alkoxy-6-pentadecylphenyl)methyl]thio]-1H-benzimidazoles/benzothiazoles and benzoxazoles from anacardic acid and investigated their ability to inhibit human cyclooxygenase-2 enzyme (COX-2). The active compounds were screened for cyclooxygenase-1 (COX-1) inhibition. Compound 13 is 384-fold and 19 is more than 470-fold selective towards COX-2 compared to COX-1. Thus, this class of compounds may serve as excellent candidates for selective COX-2 inhibition.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Benzimidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Benzothiazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Benzoxazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2 Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Heterocyclic Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PTGS1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/PTGS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazoles,
http://linkedlifedata.com/resource/pubmed/chemical/benzothiazole
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
657-60
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12639552-Benzimidazoles,
pubmed-meshheading:12639552-Benzothiazoles,
pubmed-meshheading:12639552-Benzoxazoles,
pubmed-meshheading:12639552-Blood,
pubmed-meshheading:12639552-Cyclooxygenase 1,
pubmed-meshheading:12639552-Cyclooxygenase 2,
pubmed-meshheading:12639552-Cyclooxygenase 2 Inhibitors,
pubmed-meshheading:12639552-Cyclooxygenase Inhibitors,
pubmed-meshheading:12639552-Drug Evaluation, Preclinical,
pubmed-meshheading:12639552-Heterocyclic Compounds,
pubmed-meshheading:12639552-Humans,
pubmed-meshheading:12639552-Inhibitory Concentration 50,
pubmed-meshheading:12639552-Isoenzymes,
pubmed-meshheading:12639552-Membrane Proteins,
pubmed-meshheading:12639552-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:12639552-Structure-Activity Relationship,
pubmed-meshheading:12639552-Thiazoles
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pubmed:year |
2003
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pubmed:articleTitle |
Design, synthesis and biological evaluation of benzimidazole/benzothiazole and benzoxazole derivatives as cyclooxygenase inhibitors.
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pubmed:affiliation |
Vittal Mallya Scientific Research Foundation, PO Box #406, K. R. Road, Bangalore 560 004, India.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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