Linked Life Data

12639312

Source:http://linkedlifedata.com/resource/pubmed/id/12639312

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1513
pubmed:dateCreated
2003-3-17
pubmed:abstractText
The concept of a phylotypic stage, when all vertebrate embryos show low phenotypic diversity, is an important cornerstone underlying modern developmental biology. Many theories involving patterns of development, developmental modules, mechanisms of development including developmental integration, and the action of natural selection on embryological stages have been proposed with reference to the phylotypic stage. However, the phylotypic stage has never been precisely defined, or conclusively supported or disproved by comparative quantitative data. We tested the predictions of the 'developmental hourglass' definition of the phylotypic stage quantitatively by looking at the pattern of developmental-timing variation across vertebrates as a whole and within mammals. For both datasets, the results using two different metrics were counter to the predictions of the definition: phenotypic variation between species was highest in the middle of the developmental sequence. This surprising degree of developmental character independence argues against the existence of a phylotypic stage in vertebrates. Instead, we hypothesize that numerous tightly delimited developmental modules exist during the mid-embryonic period. Further, the high level of timing changes (heterochrony) between these modules may be an important evolutionary mechanism giving rise to the diversity of vertebrates. The onus is now clearly on proponents of the phylotypic stage to present both a clear definition of it and quantitative data supporting its existence.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12639312-10449359, http://linkedlifedata.com/resource/pubmed/commentcorrection/12639312-10472187, http://linkedlifedata.com/resource/pubmed/commentcorrection/12639312-11479918, http://linkedlifedata.com/resource/pubmed/commentcorrection/12639312-11533718, http://linkedlifedata.com/resource/pubmed/commentcorrection/12639312-12116482, http://linkedlifedata.com/resource/pubmed/commentcorrection/12639312-12168621, http://linkedlifedata.com/resource/pubmed/commentcorrection/12639312-12475051, http://linkedlifedata.com/resource/pubmed/commentcorrection/12639312-7579514, http://linkedlifedata.com/resource/pubmed/commentcorrection/12639312-8094230, http://linkedlifedata.com/resource/pubmed/commentcorrection/12639312-8098845, http://linkedlifedata.com/resource/pubmed/commentcorrection/12639312-8589427, http://linkedlifedata.com/resource/pubmed/commentcorrection/12639312-8612960, http://linkedlifedata.com/resource/pubmed/commentcorrection/12639312-9278154, http://linkedlifedata.com/resource/pubmed/commentcorrection/12639312-9385839
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0962-8452
pubmed:author
pubmed:issnType
Print
pubmed:day
22
pubmed:volume
270
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
341-6
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Inverting the hourglass: quantitative evidence against the phylotypic stage in vertebrate development.
pubmed:affiliation
Institute of Evolutionary and Ecological Sciences, Leiden University, Kaiserstraat 63, PO Box 9516, The Netherlands. olaf.bininda@tierzucht.tum.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't