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rdf:type |
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lifeskim:mentions |
umls-concept:C0028128,
umls-concept:C0030685,
umls-concept:C0391871,
umls-concept:C0680255,
umls-concept:C1143489,
umls-concept:C1280500,
umls-concept:C1283071,
umls-concept:C1430239,
umls-concept:C1533691,
umls-concept:C1882561,
umls-concept:C1963578
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pubmed:issue |
2
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pubmed:dateCreated |
2003-3-12
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pubmed:abstractText |
Lipopolysaccharides (LPS), released by Gram-negative bacteria, cause vascular expression of inducible nitric oxide synthase (iNOS) leading to nitric oxide (NO) production and septic shock. Human cathelicidin antimicrobial peptide (LL-37) can bind and neutralize LPS. We wanted to study whether LL-37 affects LPS or interleukin-1beta (IL-1beta)-induced production, release and function of NO in intact rat aorta rings and cultured rat aorta smooth muscle cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antimicrobial Cationic Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/CAP18 lipopolysaccharide-binding...,
http://linkedlifedata.com/resource/pubmed/chemical/Cathelicidins,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/NOS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrates,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Nos2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Vasoconstrictor Agents,
http://linkedlifedata.com/resource/pubmed/chemical/cathelicidin antimicrobial peptide
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0001-5172
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pubmed:author |
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pubmed:copyrightInfo |
Copyright Acta Anaesthesiologica Scandinavica 47 (2003)
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pubmed:issnType |
Print
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
213-20
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pubmed:dateRevised |
2011-10-27
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pubmed:meshHeading |
pubmed-meshheading:12631052-Animals,
pubmed-meshheading:12631052-Antimicrobial Cationic Peptides,
pubmed-meshheading:12631052-Aorta, Thoracic,
pubmed-meshheading:12631052-Apoptosis,
pubmed-meshheading:12631052-Blotting, Western,
pubmed-meshheading:12631052-Cathelicidins,
pubmed-meshheading:12631052-Cells, Cultured,
pubmed-meshheading:12631052-DNA Fragmentation,
pubmed-meshheading:12631052-Humans,
pubmed-meshheading:12631052-Lipopolysaccharides,
pubmed-meshheading:12631052-Male,
pubmed-meshheading:12631052-Muscle, Smooth, Vascular,
pubmed-meshheading:12631052-Muscle Contraction,
pubmed-meshheading:12631052-Nitrates,
pubmed-meshheading:12631052-Nitric Oxide,
pubmed-meshheading:12631052-Nitric Oxide Synthase,
pubmed-meshheading:12631052-Nitric Oxide Synthase Type II,
pubmed-meshheading:12631052-Phenylephrine,
pubmed-meshheading:12631052-Rats,
pubmed-meshheading:12631052-Rats, Sprague-Dawley,
pubmed-meshheading:12631052-Vasoconstrictor Agents
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pubmed:year |
2003
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pubmed:articleTitle |
Effects of human cathelicidin antimicrobial peptide LL-37 on lipopolysaccharide-induced nitric oxide release from rat aorta in vitro.
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pubmed:affiliation |
Department of Anaesthesiology and Intensive Care, Lund University, Lund, Sweden.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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