Linked Life Data

12626604

Source:http://linkedlifedata.com/resource/pubmed/id/12626604

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2003-3-10
pubmed:abstractText
Chronic infection with hepatitis C virus (HCV) is associated with disturbances of B lymphocyte activation and function: autoantibody production, mixed cryoglobulinemia, and B cell lymphomas. It has been proposed that these abnormalities reflect chronic antigenic stimulation or aberrant signaling through the B cell coreceptor, the latter mediated by binding of the HCV E2 glycoprotein to CD81. To test this hypothesis, we measured expression of activation and differentiation markers on peripheral blood B cells from patients with chronic HCV infection. Thirty-six HCV patients with and without mixed cryoglobulinemia were compared with 18 healthy control volunteers and 17 sustained virologic responders who had cleared HCV infection. Ten of the 36 HCV patient samples showed increased B cell frequencies; B cell frequency was higher in patients with more severe hepatic fibrosis. However, these samples lacked evidence of Ag-driven activation or proliferation. The expanded cells were low in the activation markers CD25, CD69, CD71, CD80, and CD86. Proliferation of circulating B cells was unchanged in HCV patients. These cells did not express the differentiation marker CD27, suggesting that they were not enriched in memory B cells. Furthermore, the expanded B cells expressed both IgD and IgM, suggesting that they were antigenically naive. Together, these results indicate that B cell expansion in the peripheral blood of HCV patients is not associated with Ag-mediated activation and differentiation. Instead, factors other than antigenic stimulation may promote the accumulation of peripheral blood B cells with a naive phenotype in a subset of HCV patients.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
170
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3429-39
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:12626604-Adolescent, pubmed-meshheading:12626604-Adult, pubmed-meshheading:12626604-Aged, pubmed-meshheading:12626604-Antigens, CD, pubmed-meshheading:12626604-Antigens, CD27, pubmed-meshheading:12626604-Antigens, CD5, pubmed-meshheading:12626604-Antigens, CD81, pubmed-meshheading:12626604-B-Lymphocyte Subsets, pubmed-meshheading:12626604-Cell Division, pubmed-meshheading:12626604-Female, pubmed-meshheading:12626604-Flow Cytometry, pubmed-meshheading:12626604-Hepatitis C, pubmed-meshheading:12626604-Humans, pubmed-meshheading:12626604-Immunophenotyping, pubmed-meshheading:12626604-Interphase, pubmed-meshheading:12626604-Ligands, pubmed-meshheading:12626604-Lymphocyte Activation, pubmed-meshheading:12626604-Lymphocyte Count, pubmed-meshheading:12626604-Male, pubmed-meshheading:12626604-Membrane Proteins, pubmed-meshheading:12626604-Middle Aged, pubmed-meshheading:12626604-Severity of Illness Index, pubmed-meshheading:12626604-Viral Envelope Proteins
pubmed:year
2003
pubmed:articleTitle
Accumulation of B lymphocytes with a naive, resting phenotype in a subset of hepatitis C patients.
pubmed:affiliation
Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10021, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't