Source:http://linkedlifedata.com/resource/pubmed/id/12623219
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0019564,
umls-concept:C0021469,
umls-concept:C0030685,
umls-concept:C0036751,
umls-concept:C0060993,
umls-concept:C0206128,
umls-concept:C0391871,
umls-concept:C0680255,
umls-concept:C1280500,
umls-concept:C1283071,
umls-concept:C1515655,
umls-concept:C1879547,
umls-concept:C1963578,
umls-concept:C2349975
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| pubmed:issue |
2
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| pubmed:dateCreated |
2003-3-7
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| pubmed:abstractText |
The microdialysis technique was used to examine interactions between 5-HT(1A) and galanin receptors in the dorsal raphe nucleus (DRN), by measuring the extracellular levels of 5-HT in the ventral hippocampus of awake rats. The rats were pretreated with the 5-HT(1A) receptor agonist (R,S)-8-OH-DPAT (0.3 mg/kg, s.c.) or saline. 8-OH-DPAT caused a time-dependent reduction of basal 5-HT levels down to 43-48% at 40 min while at 140 min, the hippocampal 5-HT had returned to control values. At that time point, the rats received a second injection of 8-OH-DPAT or galanin (0.15, 0.5 and 1.5 nmol/0.5 microl) infused into the lateral ventricle. The second injection of 8-OH-DPAT caused a significantly smaller reduction of hippocampal 5-HT levels. In contrast, galanin at all three doses in the 8-OH-DPAT-pretreated groups, was significantly more potent in reducing 5-HT levels (maximal reduction to 74%, 52% and 49%, respectively) than it was in saline-pretreated rats (maximal reduction to 96%, 85% and 69%, respectively). The inhibitory effect of galanin (1.5 nmol) on extracellular 5-HT levels in the rat hippocampus was significantly attenuated by co-administration of the 5-HT(1A) receptor antagonists WAY-100635 (0.3 and 0.6 mg/kg s.c.) and, to a lesser extent, with pindolol (20 mg/kg s.c.). These data provide direct in vivo evidence of agonistic 5-HT(1A)-galanin receptor interaction at the presynaptic level. Furthermore, the findings indicate that a down-regulation of the somato-dendritic 5-HT(1A) autoreceptors, following their stimulation with 8-OH-DPAT and possibly also indirectly with 5-HT reuptake inhibitors, may be compensated by a subsequent 'sensitization' of the inhibitory galanin receptors in the DRN. Thus, the enhanced galanin receptor-mediated inhibition of 5-HT neurotransmission may contribute to the pathophysiology of depression or to the reduced and delayed efficacy of antidepressant therapies.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/8-Hydroxy-2-(di-n-propylamino)tetral...,
http://linkedlifedata.com/resource/pubmed/chemical/Autoreceptors,
http://linkedlifedata.com/resource/pubmed/chemical/Galanin,
http://linkedlifedata.com/resource/pubmed/chemical/Pindolol,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin, 5-HT1,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Receptor Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/WAY 100635
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| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
0028-3908
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
44
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
206-13
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| pubmed:dateRevised |
2010-11-18
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| pubmed:meshHeading |
pubmed-meshheading:12623219-8-Hydroxy-2-(di-n-propylamino)tetralin,
pubmed-meshheading:12623219-Animals,
pubmed-meshheading:12623219-Autoreceptors,
pubmed-meshheading:12623219-Dose-Response Relationship, Drug,
pubmed-meshheading:12623219-Drug Interactions,
pubmed-meshheading:12623219-Extracellular Space,
pubmed-meshheading:12623219-Galanin,
pubmed-meshheading:12623219-Hippocampus,
pubmed-meshheading:12623219-Male,
pubmed-meshheading:12623219-Microdialysis,
pubmed-meshheading:12623219-Pindolol,
pubmed-meshheading:12623219-Piperazines,
pubmed-meshheading:12623219-Pyridines,
pubmed-meshheading:12623219-Raphe Nuclei,
pubmed-meshheading:12623219-Rats,
pubmed-meshheading:12623219-Rats, Sprague-Dawley,
pubmed-meshheading:12623219-Receptors, Serotonin,
pubmed-meshheading:12623219-Receptors, Serotonin, 5-HT1,
pubmed-meshheading:12623219-Serotonin,
pubmed-meshheading:12623219-Serotonin Antagonists,
pubmed-meshheading:12623219-Serotonin Receptor Agonists,
pubmed-meshheading:12623219-Time Factors
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| pubmed:year |
2003
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| pubmed:articleTitle |
Activation of 5-HT(1A) autoreceptors enhances the inhibitory effect of galanin on hippocampal 5-HT release in vivo.
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| pubmed:affiliation |
Department of Neuroscience, Karolinska Institutet, Retzius väg 8, 171 77 Stockholm, Sweden.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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