Source:http://linkedlifedata.com/resource/pubmed/id/12620642
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
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pubmed:dateCreated |
2003-3-6
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pubmed:abstractText |
In multiple sclerosis (MS), matrix metalloproteinase (MMP) activity in tissues is the result of a balance between MMPs and their tissue inhibitors (TIMPs). MMP-9 predominates in acute MS lesions and is inhibited by TIMP-1, while MMP-2 may participate in the remodeling of the extracellular matrix (ECM) such as in chronic disease and is inhibited by TIMP-2. These differences may be reflected in serum and cerebrospinal fluid (CSF). We have tried to characterize MMP-2 and MMP-9 activities, in relation to their respective TIMPs, 2 and 1, as a factor of different types of the disease, as this information was not previously clearly stated. We found the MMP-2/TIMP-2 ratio in serum to show higher values in secondary progressive (SP, p=0.02) and primary progressive (PP, p=0.01) MS than short disease duration (SDD) relapsing-remitting (RR) MS, but not different from the healthy control (HC) group. Whereas the MMP-9/TIMP-1 ratio in serum showed higher (p=0.04) values in SDD RR MS than PP but also in active patients, evaluated either clinically (p=0.006) or from the magnetic resonance imaging (MRI, p<0.05), compared to inactive disease. CSF MMP to TIMP ratios did not differ between MS subtypes, suggesting systemic rather CNS-restricted changes. These results show that an increase in MMP-2/TIMP-2 ratio marks chronic progression in MS, but it is as high as in HC, and also confirm that high MMP-9 activity characterizes short duration relapsing and active forms of the disease.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 9,
http://linkedlifedata.com/resource/pubmed/chemical/Tissue Inhibitor of...,
http://linkedlifedata.com/resource/pubmed/chemical/Tissue Inhibitor of...
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0165-5728
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
136
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
46-53
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12620642-Adult,
pubmed-meshheading:12620642-Central Nervous System,
pubmed-meshheading:12620642-Cerebrospinal Fluid,
pubmed-meshheading:12620642-Female,
pubmed-meshheading:12620642-Humans,
pubmed-meshheading:12620642-Immunoglobulin G,
pubmed-meshheading:12620642-Leukocyte Count,
pubmed-meshheading:12620642-Male,
pubmed-meshheading:12620642-Matrix Metalloproteinase 2,
pubmed-meshheading:12620642-Matrix Metalloproteinase 9,
pubmed-meshheading:12620642-Middle Aged,
pubmed-meshheading:12620642-Multiple Sclerosis,
pubmed-meshheading:12620642-Nerve Fibers, Myelinated,
pubmed-meshheading:12620642-Tissue Inhibitor of Metalloproteinase-1,
pubmed-meshheading:12620642-Tissue Inhibitor of Metalloproteinase-2,
pubmed-meshheading:12620642-Up-Regulation
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pubmed:year |
2003
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pubmed:articleTitle |
Serum MMP-2 and MMP-9 are elevated in different multiple sclerosis subtypes.
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pubmed:affiliation |
Neurology Unit, University of Foggia, Italy.
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pubmed:publicationType |
Journal Article
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