Linked Life Data

12620219

Source:http://linkedlifedata.com/resource/pubmed/id/12620219

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2003-3-6
pubmed:abstractText
Interleukin-1 receptor-associated kinase (IRAK) was first described as a signal transducer for the proinflammatory cytokine interleukin-1 (IL-1) and was later implicated in signal transduction of other members of the Toll-like receptor (TLR)/IL-1 receptor (IL-1R) family. In the meantime, four different IRAK-like molecules have been identified: two active kinases, IRAK-1 and IRAK-4, and two inactive kinases, IRAK-2 and IRAK-M. All IRAKs mediate activation of nuclear factor-kappaB (NF-kappaB) and mitogen-activated protein kinase (MAPK) pathways. Although earlier observations suggested that IRAKs have redundant functions, this hypothesis is now challenged by knockout studies. Furthermore, recent data imply a role for IRAK-1 in tumor necrosis factor receptor (TNFR) superfamily-induced signaling pathways as well. The scope of this review is to highlight the specific role of different IRAKs and to discuss several mechanisms that contribute to their activation and regulation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1097-2765
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
293-302
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:12620219-Amino Acid Sequence, pubmed-meshheading:12620219-Animals, pubmed-meshheading:12620219-Drosophila Proteins, pubmed-meshheading:12620219-Gene Expression, pubmed-meshheading:12620219-Humans, pubmed-meshheading:12620219-Interleukin-1 Receptor-Associated Kinases, pubmed-meshheading:12620219-Membrane Glycoproteins, pubmed-meshheading:12620219-Models, Biological, pubmed-meshheading:12620219-Molecular Sequence Data, pubmed-meshheading:12620219-Phosphotransferases (Alcohol Group Acceptor), pubmed-meshheading:12620219-Protein Kinases, pubmed-meshheading:12620219-Protein Structure, Tertiary, pubmed-meshheading:12620219-Receptors, Cell Surface, pubmed-meshheading:12620219-Receptors, Interleukin-1, pubmed-meshheading:12620219-Sequence Homology, Amino Acid, pubmed-meshheading:12620219-Signal Transduction, pubmed-meshheading:12620219-Toll-Like Receptors
pubmed:year
2003
pubmed:articleTitle
Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members.
pubmed:affiliation
Department of Molecular Biomedical Research, Unit of Molecular Signal Transduction in Inflammation, Ghent University, VIB, K.L. Ledeganckstraat 35, B-9000, Ghent, Belgium.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't