Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1975-12-20
pubmed:abstractText
This paper reviews the principal effects of phenobarbital on biliary function. Phenobarbital administration is followed by an increase in bile flow. This is mainly due to an increase in the bile salt-independent fraction of canalicular bile flow possibly through an increase in canilicular Na+-K+ ATPase activity. In addition, bile salt excretion may be increased. This effect of barbiturates on choleresis appears to be independent of microsomal enzyme induction. Barbiturates increase the uptake, storage and excretion of various dyes, for example sulfobromophthalein. Phenobarbital increases bilirubin clearance by the liver; it enhances bilirubin-UDP-glucuronyl transferase activity; whether the influence on bilirubin clearance is related to the effect on the enzyme is unknown. The influence of phenobarbital on biliary lipids is markedly different from one species to the other. In the rhesus monkey and in the rat, the relative concentration of cholesterol is decreased; in the hamster it is increased, and in man it appears largely unaffected. These effects of phenobarbital have been utilized in the treatment of chronic unconjugated hyperbilirubinemia and of certain cholestatic syndromes. Phenobarbital alone has been useful, so far, in the treatment of cholesterol gallstones.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0012-2823
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
43-56
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:126185-Adenosine Triphosphatases, pubmed-meshheading:126185-Animals, pubmed-meshheading:126185-Bile, pubmed-meshheading:126185-Bile Acids and Salts, pubmed-meshheading:126185-Biliary Tract, pubmed-meshheading:126185-Bilirubin, pubmed-meshheading:126185-Cholelithiasis, pubmed-meshheading:126185-Cholestasis, pubmed-meshheading:126185-Cholesterol, pubmed-meshheading:126185-Cytochrome P-450 Enzyme System, pubmed-meshheading:126185-Depression, Chemical, pubmed-meshheading:126185-Haplorhini, pubmed-meshheading:126185-Humans, pubmed-meshheading:126185-Hyperbilirubinemia, pubmed-meshheading:126185-Infant, Newborn, pubmed-meshheading:126185-Jaundice, Chronic Idiopathic, pubmed-meshheading:126185-Liver, pubmed-meshheading:126185-Macaca mulatta, pubmed-meshheading:126185-Phenobarbital, pubmed-meshheading:126185-Phospholipids, pubmed-meshheading:126185-Rats, pubmed-meshheading:126185-Secretory Rate, pubmed-meshheading:126185-Stimulation, Chemical, pubmed-meshheading:126185-Sulfobromophthalein
pubmed:year
1975
pubmed:articleTitle
Barbituates and biliary function.
pubmed:publicationType
Journal Article