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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2003-3-5
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pubmed:abstractText |
This paper deals with the synthesis of a novel series of amphiphilic glycosylated spin-traps derived from alpha-Phenyl-N-tert-butyl nitrone (PBN) and an initial characterization of their anti-caspase-3 activity. Preliminary investigation of their anti-apoptosis effect showed they dramatically inhibit the activity of caspase-3 in cultured neuronal cells following induction of apoptosis by hydrogen peroxide.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
859-62
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pubmed:meshHeading |
pubmed-meshheading:12617908-Antioxidants,
pubmed-meshheading:12617908-Apoptosis,
pubmed-meshheading:12617908-Caspases,
pubmed-meshheading:12617908-Cell Survival,
pubmed-meshheading:12617908-Cells, Cultured,
pubmed-meshheading:12617908-Glycosylation,
pubmed-meshheading:12617908-Hydrogen Peroxide,
pubmed-meshheading:12617908-Neurodegenerative Diseases,
pubmed-meshheading:12617908-Neurons,
pubmed-meshheading:12617908-Neuroprotective Agents,
pubmed-meshheading:12617908-Nitrogen Oxides,
pubmed-meshheading:12617908-Oxidation-Reduction,
pubmed-meshheading:12617908-Spin Trapping
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pubmed:year |
2003
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pubmed:articleTitle |
Synthesis of a new family of glycolipidic nitrones as potential antioxidant drugs for neurodegenerative disorders.
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pubmed:affiliation |
Laboratoire de Chimie BioOrganique et des Systèmes Moléculaire Vectoriels, Faculté des Sciences, 33 rue Louis Pasteur, 84000 Avignon, France.
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pubmed:publicationType |
Journal Article
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