Source:http://linkedlifedata.com/resource/pubmed/id/12615619
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
2003-4-25
|
| pubmed:abstractText |
Sarcoidosis, in the United States, more commonly and severely affects African Americans. HLA associations with sarcoidosis have been reported, but most studies used case-control designs, which may produce biased results because of population stratification. We examined transmission of HLA-DQB1 alleles in 225 African American families with at least one offspring with sarcoidosis. Of five low-resolution HLA-DQB1 alleles, *02 and *06 showed significant deviation in transmission patterns to affected offspring. High-resolution typing of these allelic subsets revealed that HLA-DQB1*0201 was transmitted to affected offspring half as often as expected (p = 0.001), whereas DQB1*0602 was transmitted to affected offspring about 20% more often than expected (p = 0.029). Examining interactions between *0201 and *0602 alleles and environmental exposures showed that *0602 varied little with respect to exposure, but sarcoidosis risk associated with *0201 often depended on exposure status. Alternatively, the *0602 allele in affected probands was associated with radiographic disease progression, but the *0201 allele showed no significant correlation with phenotype. Major differences in the amino acid sequences encoded by *0201 and *0602 alleles exist, which may explain the differential effects these alleles have on sarcoidosis susceptibility and progression in African Americans.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
1073-449X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
167
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1225-31
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:12615619-African Continental Ancestry Group,
pubmed-meshheading:12615619-Alleles,
pubmed-meshheading:12615619-Case-Control Studies,
pubmed-meshheading:12615619-Disease Progression,
pubmed-meshheading:12615619-Environmental Exposure,
pubmed-meshheading:12615619-Gene Frequency,
pubmed-meshheading:12615619-Genes, Dominant,
pubmed-meshheading:12615619-Genetic Predisposition to Disease,
pubmed-meshheading:12615619-Genetic Variation,
pubmed-meshheading:12615619-Genotype,
pubmed-meshheading:12615619-HLA-DQ Antigens,
pubmed-meshheading:12615619-HLA-DQ beta-Chains,
pubmed-meshheading:12615619-Humans,
pubmed-meshheading:12615619-Immunity, Innate,
pubmed-meshheading:12615619-Linkage Disequilibrium,
pubmed-meshheading:12615619-Membrane Glycoproteins,
pubmed-meshheading:12615619-Michigan,
pubmed-meshheading:12615619-Models, Genetic,
pubmed-meshheading:12615619-Pedigree,
pubmed-meshheading:12615619-Phenotype,
pubmed-meshheading:12615619-Sarcoidosis, Pulmonary,
pubmed-meshheading:12615619-Severity of Illness Index
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Sarcoidosis susceptibility and resistance HLA-DQB1 alleles in African Americans.
|
| pubmed:affiliation |
Division of Pulmonary and Critical Care Medicine, Mount Sinai Medical Center, One Gustave Levy Place, Box 1232, NY, NY 10029, USA. michael.iannuzzi@mountsinai.org
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|