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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2003-3-3
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pubmed:abstractText |
Papyriflavonol A, a new prenylated flavonol isolated from Broussonetia papyrifera, selectively inhibits recombinant human secretory phospholipase A(2)s (sPLA(2)s). Papyriflavonol A was found to inhibit human group IIA and V sPLA(2)s potently and irreversibly in a dose-dependent manner, with respective IC(50) values of 3.9 and 4.5 microM. The inhibitory effects of papyriflavonol A against bovine group IB (IC(50) of 76.9 microM) and the human group X (IC(50) of 225 microM) sPLA(2)s were weaker than those against human group IIA and V sPLA(2)s, and human group IIF sPLA(2) was not inhibited. In addition, papyriflavonol A potently inhibited the stimulus-induced production of leukotriene C(4) with an IC(50) value of approximately 0.64 microM in mouse bone marrow-derived mast cells. In addition, papyriflavonol A significantly reduced IgE-dependent passive cutaneous anaphylaxis in rats. These results indicate that papyriflavonol A provides a basis for novel types of antiinflammatory drugs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0918-6158
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pubmed:author |
pubmed-author:ChangHyeun WookHW,
pubmed-author:JungHyejinH,
pubmed-author:KangSam SikSS,
pubmed-author:KimHyun PyoHP,
pubmed-author:KudoIchiroI,
pubmed-author:KwakWie JongWJ,
pubmed-author:KwonDong YeulDY,
pubmed-author:LeeEunkyungE,
pubmed-author:LinChang XiuCX,
pubmed-author:MoonTae ChurlTC,
pubmed-author:MurakamiMakotoM,
pubmed-author:RhynHyeun GeeHG,
pubmed-author:SonKun HoKH
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
299-302
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:12612436-Animals,
pubmed-meshheading:12612436-Anti-Inflammatory Agents,
pubmed-meshheading:12612436-Baculoviridae,
pubmed-meshheading:12612436-Bone Marrow Cells,
pubmed-meshheading:12612436-Broussonetia,
pubmed-meshheading:12612436-Cells, Cultured,
pubmed-meshheading:12612436-Dose-Response Relationship, Drug,
pubmed-meshheading:12612436-Embryo, Mammalian,
pubmed-meshheading:12612436-Embryo, Nonmammalian,
pubmed-meshheading:12612436-Flavonols,
pubmed-meshheading:12612436-Humans,
pubmed-meshheading:12612436-Inhibitory Concentration 50,
pubmed-meshheading:12612436-Insects,
pubmed-meshheading:12612436-Kidney,
pubmed-meshheading:12612436-Leukotriene C4,
pubmed-meshheading:12612436-Male,
pubmed-meshheading:12612436-Mast Cells,
pubmed-meshheading:12612436-Mice,
pubmed-meshheading:12612436-Mice, Inbred BALB C,
pubmed-meshheading:12612436-Passive Cutaneous Anaphylaxis,
pubmed-meshheading:12612436-Phospholipases A,
pubmed-meshheading:12612436-Phospholipases A2,
pubmed-meshheading:12612436-Rats,
pubmed-meshheading:12612436-Rats, Sprague-Dawley
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pubmed:year |
2003
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pubmed:articleTitle |
Papyriflavonol A from Broussonetia papyrifera inhibits the passive cutaneous anaphylaxis reaction and has a secretory phospholipase A2-inhibitory activity.
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pubmed:affiliation |
SK Chemicals, Suwon-Si, Kyungki-cho, Korea.
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pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro,
Research Support, Non-U.S. Gov't
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