|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0003241,
umls-concept:C0030705,
umls-concept:C0034050,
umls-concept:C0079460,
umls-concept:C0086045,
umls-concept:C0087111,
umls-concept:C0143146,
umls-concept:C0332240,
umls-concept:C0439849,
umls-concept:C0441889,
umls-concept:C0549193,
umls-concept:C0871261,
umls-concept:C1278052,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2709248,
umls-concept:C2911692
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|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2003-3-3
|
|
pubmed:abstractText |
Conventional measures of the severity of alveolar proteinosis (AP) include alveolar-arterial oxygen gradient ([A - a]DO(2)), vital capacity (VC), and carbon monoxide transfer factor (TLCO), but alternative serological measures have been sought. Granulocyte-macrophage colony stimulating factor (GM-CSF) neutralising autoantibody is found in patients with idiopathic acquired AP. We have investigated the interrelationships between the levels of this antibody and those of surfactant protein (SP)-A and -B, lactate dehydrogenase (LDH), and conventional measures of disease severity, and the capacity of these parameters to predict the response to rhGM-CSF treatment.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
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pubmed:month |
Mar
|
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pubmed:issn |
0040-6376
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
58
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pubmed:owner |
NLM
|
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pubmed:authorsComplete |
Y
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pubmed:pagination |
252-7
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:12612307-Adolescent,
pubmed-meshheading:12612307-Adult,
pubmed-meshheading:12612307-Autoantibodies,
pubmed-meshheading:12612307-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:12612307-Female,
pubmed-meshheading:12612307-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:12612307-Humans,
pubmed-meshheading:12612307-Immunoglobulin G,
pubmed-meshheading:12612307-L-Lactate Dehydrogenase,
pubmed-meshheading:12612307-Male,
pubmed-meshheading:12612307-Middle Aged,
pubmed-meshheading:12612307-Prospective Studies,
pubmed-meshheading:12612307-Protein Precursors,
pubmed-meshheading:12612307-Proteolipids,
pubmed-meshheading:12612307-Pulmonary Alveolar Proteinosis,
pubmed-meshheading:12612307-Pulmonary Surfactant-Associated Protein A,
pubmed-meshheading:12612307-Recombinant Proteins
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|
pubmed:year |
2003
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|
pubmed:articleTitle |
Relationship of anti-GM-CSF antibody concentration, surfactant protein A and B levels, and serum LDH to pulmonary parameters and response to GM-CSF therapy in patients with idiopathic alveolar proteinosis.
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|
pubmed:affiliation |
Melbourne Tumour Biology Branch, Ludwig Institute for Cancer Research, Melbourne, Australia. jseymour@petermac.unimelb.edu.au
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
|
