Linked Life Data

12608631

Source:http://linkedlifedata.com/resource/pubmed/id/12608631

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2003-2-28
pubmed:abstractText
Ginsenosides are the major principles of Panax ginseng and have various pharmacological actions on the central nervous system. In this report, we investigated whether ginsenoside Rb1 (10, 100 nmol(-1), icv) could increase the population spike (PS) amplitude in a dose-dependent manner, and accelerate the maintenance phase of long-term potentiation (LTP) induced by high frequency stimulation (HFS) in the dentate gyrus of anaesthetized rats. However, it had no effect on basic synaptic responses evoked by test stimulation. Comparatively, ginsenoside Rb1 (10, 100 nmol l(-1), icv) inhibited the induction phase of LTP induced by HFS in a dose-dependent manner. This may be one of the mechanisms of action of ginsenoside Rb1 on synaptic transmission. The details of the mechanism need further investigation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1028-6020
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-4
pubmed:dateRevised
2009-7-21
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Effect of ginsenoside Rb1 on long-term potentiation in the dentate gyrus of anaesthetized rats.
pubmed:affiliation
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China.
pubmed:publicationType
Journal Article