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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-3
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pubmed:dateCreated |
2003-2-27
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pubmed:abstractText |
The C-terminal region of adenovirus E1A interacts with the transcriptional corepressor, CtBP. The mechanism of transcriptional regulation by CtBP is not known. CtBP shares a significant homology with NAD(+)-dependent D2-hydroxy acid dehydrogenases. CtBP binds to NAD(+) and NADH. Both forms of the dinucleotide stimulate oligomerization of native CtBP and enhance complex formation with E1A. CtBP also has a slow dehydrogenase activity. Interaction of CtBP with E1A reduces the dehydrogenase activity. Our results raise the possibility that the oxidation/reduction reactions of CtBP may regulate transcription. Thus, CtBP is a unique transcriptional regulator with an enzymatic activity similar to metabolic dehydrogenases. The levels of intracellular nicotinamide adenine dinucleotide may modulate transcriptional activity of CtBP.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
537
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
157-60
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12606049-Adenovirus E1A Proteins,
pubmed-meshheading:12606049-Alcohol Oxidoreductases,
pubmed-meshheading:12606049-Amino Acid Sequence,
pubmed-meshheading:12606049-Animals,
pubmed-meshheading:12606049-Binding Sites,
pubmed-meshheading:12606049-Cloning, Molecular,
pubmed-meshheading:12606049-DNA-Binding Proteins,
pubmed-meshheading:12606049-Escherichia coli,
pubmed-meshheading:12606049-Kinetics,
pubmed-meshheading:12606049-Macromolecular Substances,
pubmed-meshheading:12606049-NAD,
pubmed-meshheading:12606049-Oxidation-Reduction,
pubmed-meshheading:12606049-Oxidoreductases,
pubmed-meshheading:12606049-Phosphoproteins,
pubmed-meshheading:12606049-Recombinant Proteins,
pubmed-meshheading:12606049-Vertebrates
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pubmed:year |
2003
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pubmed:articleTitle |
Nicotinamide adenine dinucleotide stimulates oligomerization, interaction with adenovirus E1A and an intrinsic dehydrogenase activity of CtBP.
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pubmed:affiliation |
Institute for Molecular Virology, Saint Louis University Health Sciences Center, 3681 Park Avenue, MO 63110, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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