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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2003-2-26
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pubmed:abstractText |
Establishing the existence of alpha-adrenoceptor subtypes in isolated human gastroepiploic and omental arteries was the goal of the present study. Functional vascular reactivity of selective alpha(1)- and alpha(2)-adrenoceptor agonists and antagonists was studied, using a cannula inserting technique. Intraluminal administration of norepinephrine (NE), phenylephrine (PE) or BHT-933 caused a vasoconstrictive response in a dose-related manner. The relative potencies of the 3 agonists were almost the same in both arteries. NE-induced vasoconstrictions were significantly antagonized by either prazosin or rauwolscine. PE-induced responses were strongly inhibited by prazosin. BHT-933-induced constrictions were inhibited by rauwolscine. These results indicate that both alpha(1)- and alpha(2)-adrenoceptors exist in the human gastroepiploic and omental arteries.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-1 Receptor Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-1 Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-2 Receptor Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-2 Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Azepines,
http://linkedlifedata.com/resource/pubmed/chemical/B-HT 933,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Prazosin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha-1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha-2,
http://linkedlifedata.com/resource/pubmed/chemical/Yohimbine
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1346-9843
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
259-62
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:12604878-Adrenergic alpha-1 Receptor Agonists,
pubmed-meshheading:12604878-Adrenergic alpha-1 Receptor Antagonists,
pubmed-meshheading:12604878-Adrenergic alpha-2 Receptor Agonists,
pubmed-meshheading:12604878-Adrenergic alpha-2 Receptor Antagonists,
pubmed-meshheading:12604878-Aged,
pubmed-meshheading:12604878-Arteries,
pubmed-meshheading:12604878-Azepines,
pubmed-meshheading:12604878-Catheterization,
pubmed-meshheading:12604878-Dose-Response Relationship, Drug,
pubmed-meshheading:12604878-Female,
pubmed-meshheading:12604878-Gastroepiploic Artery,
pubmed-meshheading:12604878-Humans,
pubmed-meshheading:12604878-Male,
pubmed-meshheading:12604878-Middle Aged,
pubmed-meshheading:12604878-Norepinephrine,
pubmed-meshheading:12604878-Peritoneum,
pubmed-meshheading:12604878-Phenylephrine,
pubmed-meshheading:12604878-Prazosin,
pubmed-meshheading:12604878-Receptors, Adrenergic, alpha,
pubmed-meshheading:12604878-Receptors, Adrenergic, alpha-1,
pubmed-meshheading:12604878-Receptors, Adrenergic, alpha-2,
pubmed-meshheading:12604878-Vasoconstriction,
pubmed-meshheading:12604878-Yohimbine
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pubmed:year |
2003
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pubmed:articleTitle |
Existence of alpha-adrenoceptor subtypes in isolated human gastroepiploic and omental arteries.
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pubmed:affiliation |
Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
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pubmed:publicationType |
Journal Article,
In Vitro
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