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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2003-3-27
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pubmed:abstractText |
Most of the peptides presented by major histocompatibility complex (MHC) class I molecules require processing by proteasomes. Tripeptidyl peptidase II (TPPII), an aminopeptidase with endoproteolytic activity, may also have a role in antigen processing. Here, we analyzed the processing and presentation of the immunodominant human immunodeficiency virus epitope HIV-Nef(73-82) in human dendritic cells. We found that inhibition of proteasome activity did not impair Nef(73-82) epitope presentation. In contrast, specific inhibition of TPPII led to a reduction of Nef(73-82) epitope presentation. We propose that TPPII can act in combination with or independent of the proteasome system and can generate epitopes that evade generation by the proteasome-system.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aminopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Bacterial Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Cysteine Endopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/Dipeptidyl-Peptidases and...,
http://linkedlifedata.com/resource/pubmed/chemical/Endopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class I,
http://linkedlifedata.com/resource/pubmed/chemical/Multienzyme Complexes,
http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Proteasome Endopeptidase Complex,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/epoxomicin
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1529-2908
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pubmed:author |
pubmed-author:AndrieuMurielM,
pubmed-author:DesoutterJean-FrançoisJF,
pubmed-author:DiescherSusanneS,
pubmed-author:GalyAnneA,
pubmed-author:HaasGabyG,
pubmed-author:HenkleinPeterP,
pubmed-author:HosmalinAnneA,
pubmed-author:JanekKatharinaK,
pubmed-author:KloetzelPeter-MPM,
pubmed-author:LaderachDiegoD,
pubmed-author:MarañónConcepciónC,
pubmed-author:ReissYuvalY,
pubmed-author:SchildHansjörgH,
pubmed-author:SeifertUlrikeU,
pubmed-author:ShmueliAyeletA,
pubmed-author:WeinschenkToniT,
pubmed-author:WesoloskiLisaL,
pubmed-author:de la SalleHenriH
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
375-9
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pubmed:dateRevised |
2009-12-11
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pubmed:meshHeading |
pubmed-meshheading:12598896-Aminopeptidases,
pubmed-meshheading:12598896-Anti-Bacterial Agents,
pubmed-meshheading:12598896-Antigen Presentation,
pubmed-meshheading:12598896-Cysteine Endopeptidases,
pubmed-meshheading:12598896-Dendritic Cells,
pubmed-meshheading:12598896-Dipeptidyl-Peptidases and Tripeptidyl-Peptidases,
pubmed-meshheading:12598896-Endopeptidases,
pubmed-meshheading:12598896-Epitopes,
pubmed-meshheading:12598896-HIV,
pubmed-meshheading:12598896-Histocompatibility Antigens Class I,
pubmed-meshheading:12598896-Humans,
pubmed-meshheading:12598896-Multienzyme Complexes,
pubmed-meshheading:12598896-Oligopeptides,
pubmed-meshheading:12598896-Proteasome Endopeptidase Complex,
pubmed-meshheading:12598896-RNA, Small Interfering
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pubmed:year |
2003
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pubmed:articleTitle |
An essential role for tripeptidyl peptidase in the generation of an MHC class I epitope.
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pubmed:affiliation |
Institut für Biochemie-Charité, Medical Faculty of the Humboldt-University Berlin, Monbijoustr. 2, 10117 Berlin, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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