Source:http://linkedlifedata.com/resource/pubmed/id/12598722
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2003-2-24
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pubmed:abstractText |
Using the whole-cell configuration of the patch-clamp recording method, we analyzed the role of K+ conductances in determining the characteristics of the dendritically-initiated low-threshold Ca+ spike (LTS) recorded at the somatic level of rat cerebellar Purkinje cells (PCs) in slice cultures. Blockade of tetra-ethyl-ammonium-(TEA)- and 4-aminopyridine-(4-AP)-sensitive K+ channels increased the amplitude of the LTS. This effect was prominent with 4-AP, which promotes the fast-decaying component of the LTS. Surprisingly, a shortening of the LTS was induced by the blockade of K+ channel activity instead of a broadening of spikes as generally observed. We propose that, when propagating to the soma, TEA- and 4-AP-sensitive K+ channel activity affects the electrical properties of dendrites such that the LTS is attenuated and slowed down.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0959-4965
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
167-71
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12598722-Action Potentials,
pubmed-meshheading:12598722-Animals,
pubmed-meshheading:12598722-Calcium Channels,
pubmed-meshheading:12598722-Cerebellum,
pubmed-meshheading:12598722-Potassium Channel Blockers,
pubmed-meshheading:12598722-Potassium Channels,
pubmed-meshheading:12598722-Purkinje Cells,
pubmed-meshheading:12598722-Rats
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pubmed:year |
2003
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pubmed:articleTitle |
K+ channel activation and low-threshold Ca2+ spike of rat cerebellar Purkinje cells in vitro.
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pubmed:affiliation |
Laboratoire de Neurobiologie Cellulaire, CNRS, Centre de Neurochimie, F-67084 Strasbourg Cedex, France.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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