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rdf:type |
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lifeskim:mentions |
umls-concept:C0003316,
umls-concept:C0007570,
umls-concept:C0020792,
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C0205314,
umls-concept:C0679622,
umls-concept:C0871261,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1511978,
umls-concept:C1704632,
umls-concept:C1706438,
umls-concept:C1706817,
umls-concept:C2698600,
umls-concept:C2911692
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pubmed:issue |
5
|
|
pubmed:dateCreated |
2003-2-20
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|
pubmed:abstractText |
One of the diagnostic hallmarks of the histological lesions associated with celiac disease is the extensive infiltration of the small intestinal epithelium by CD8(+) T cells of unknown Ag specificity. In this study, we report recognition of the gliadin-derived peptide (A-gliadin 123-132) by CD8(+) T lymphocytes from celiac patients. A-gliadin 123-132-specific IFN-gamma production and cytotoxic activity were detected in PBMCs derived from patients on gluten-free diet, but not from either celiac patients on gluten-containing diet or healthy controls. In contrast, A-gliadin 123-132-specific cells were isolated from small intestine biopsies of patients on either gluten-free or gluten-containing diets. Short-term T cell lines derived from the small intestinal mucosa and specific for the 123-132 epitope recognized human APC pulsed with either whole recombinant alpha-gliadin or a partial pepsin-trypsin gliadin digest. Finally, we speculate on a possible mechanism leading to processing and presentation of class I-restricted gliadin-derived epitopes in celiac disease patients.
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pubmed:grant |
|
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
|
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pubmed:issn |
0022-1767
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pubmed:author |
pubmed-author:AuricchioSalvatoreS,
pubmed-author:CosentiniElenaE,
pubmed-author:De PascaleMariateresaM,
pubmed-author:FaruoloClementinaC,
pubmed-author:GianfraniCarmenC,
pubmed-author:MugionePatriziaP,
pubmed-author:SengerStefaniaS,
pubmed-author:SetteAlessandroA,
pubmed-author:SouthwoodScottS,
pubmed-author:TerrazzanoGiuseppeG,
pubmed-author:TronconeRiccardoR
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|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
170
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
2719-26
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|
pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12594302-Adolescent,
pubmed-meshheading:12594302-Adult,
pubmed-meshheading:12594302-Antigen Presentation,
pubmed-meshheading:12594302-CD8-Positive T-Lymphocytes,
pubmed-meshheading:12594302-Celiac Disease,
pubmed-meshheading:12594302-Cell Line,
pubmed-meshheading:12594302-Cell Movement,
pubmed-meshheading:12594302-Child,
pubmed-meshheading:12594302-Child, Preschool,
pubmed-meshheading:12594302-Cytotoxicity Tests, Immunologic,
pubmed-meshheading:12594302-Epitopes, T-Lymphocyte,
pubmed-meshheading:12594302-Gliadin,
pubmed-meshheading:12594302-HLA-A2 Antigen,
pubmed-meshheading:12594302-Humans,
pubmed-meshheading:12594302-Intestinal Mucosa,
pubmed-meshheading:12594302-Peptide Fragments,
pubmed-meshheading:12594302-Protein Processing, Post-Translational,
pubmed-meshheading:12594302-T-Lymphocytes, Cytotoxic
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|
pubmed:year |
2003
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|
pubmed:articleTitle |
Celiac disease association with CD8+ T cell responses: identification of a novel gliadin-derived HLA-A2-restricted epitope.
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|
pubmed:affiliation |
Institute of Food Science and Technology, Consiglio Nazionale delle Ricerche, Avellino, Italy. cgianfrani@isa.av.cnr.it
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
