Source:http://linkedlifedata.com/resource/pubmed/id/12593646
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2003-2-20
|
| pubmed:abstractText |
Cyclosporin A is effective in the treatment of asthma patients, but its chronic use is limited by toxicity. Novel cyclosporin A analogues were synthesized utilizing the olefin metathesis reaction and evaluated in a calcineurin A inhibition assay. The novel analogues demonstrated activity comparable to activity of the parent molecule and are potential soft drugs.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0022-2623
|
| pubmed:author |
pubmed-author:ChenJason SJS,
pubmed-author:EcksteinJensJ,
pubmed-author:EninV MVM,
pubmed-author:HamannBlakeB,
pubmed-author:HoffmannEthanE,
pubmed-author:Homuth-TrombinoDanielaD,
pubmed-author:KangJane MJM,
pubmed-author:LazarovaTsvetelinaT,
pubmed-author:McClureChristopherC,
pubmed-author:OrYat SunYS
|
| pubmed:issnType |
Print
|
| pubmed:day |
27
|
| pubmed:volume |
46
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
674-6
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading | |
| pubmed:year |
2003
|
| pubmed:articleTitle |
Synthesis and biological evaluation of novel cyclosporin a analogues: potential soft drugs for the treatment of autoimmune diseases.
|
| pubmed:affiliation |
Enanta Pharmaceuticals, 500 Arsenal Street, Watertown, Massachusetts 02472, USA. tsvetelina.lazarova@sprlus.com
|
| pubmed:publicationType |
Journal Article
|