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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2003-2-19
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pubmed:abstractText |
Mixed hematopoietic chimerism after bone marrow transplantation can provide effective treatment for beta-thalassemia because of the selective advantage that exists for donor erythropoiesis. In utero hematopoietic stem cell transplantation (IUHSCTx) can achieve mixed hematopoietic chimerism, particularly when a selective advantage exists for donor cells. To investigate the biology of IUHSCTx in hemoglobinopathies, we performed fully allogeneic IUHSCTx in murine models of beta-thalassemia (Thal) and sickle cell disease (SCD).
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0301-472X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
176-84
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12591283-Anemia, Sickle Cell,
pubmed-meshheading:12591283-Animals,
pubmed-meshheading:12591283-Bone Marrow Transplantation,
pubmed-meshheading:12591283-Disease Models, Animal,
pubmed-meshheading:12591283-Erythropoiesis,
pubmed-meshheading:12591283-Female,
pubmed-meshheading:12591283-Fetal Diseases,
pubmed-meshheading:12591283-Graft Survival,
pubmed-meshheading:12591283-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:12591283-Hemoglobinopathies,
pubmed-meshheading:12591283-Hepatocytes,
pubmed-meshheading:12591283-Humans,
pubmed-meshheading:12591283-Mice,
pubmed-meshheading:12591283-Mice, Transgenic,
pubmed-meshheading:12591283-Pregnancy,
pubmed-meshheading:12591283-Transplantation, Homologous,
pubmed-meshheading:12591283-Transplantation Chimera,
pubmed-meshheading:12591283-beta-Thalassemia
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pubmed:year |
2003
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pubmed:articleTitle |
Mixed chimerism following in utero hematopoietic stem cell transplantation in murine models of hemoglobinopathy.
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pubmed:affiliation |
The Childrens Institute for Surgical Science, Department of Surgery, The Children's Hospital of Philadelphia, 3516 Civic Center Boulevard, Philadelphia, PA 19104-4399, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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