Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-3
pubmed:dateCreated
2003-2-19
pubmed:abstractText
Erectile dysfunction is common in men with chronic renal failure. Previously nitrergic and endothelium-dependent relaxation responses have been shown to be reduced in chronic renal failure rabbits. We have therefore investigated the efficacy of phosphodiesterase inhibitors on the corpora cavernosa obtained from uremic rabbits. Uremia was induced with 5/6 nephrectomy and 4 weeks later cavernosal tissue strips were isolated. The relaxant effect of phosphodiesterase 5 inhibitors, zaprinast (1-300 microM) and sildenafil (0.01-300 microM), phosphodiesterase 3 inhibitor amrinone (1-100 microM) and non-specific phosphodiesterase inhibitor papaverine (1-300 microM) were investigated on phenylephrine (10 microM)-induced tone. We found a shift in the dose-response curve of only phosphodiesterase 5 inhibitors. These results suggest that the decreased production or availability of endogenous nitric oxide in chronic renal failure animals leads to decreased efficacy of phosphodiesterase 5 inhibitors to induce relaxation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Amrinone, http://linkedlifedata.com/resource/pubmed/chemical/Calcium, http://linkedlifedata.com/resource/pubmed/chemical/Creatinine, http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes, http://linkedlifedata.com/resource/pubmed/chemical/Papaverine, http://linkedlifedata.com/resource/pubmed/chemical/Parathyroid Hormone, http://linkedlifedata.com/resource/pubmed/chemical/Phosphates, http://linkedlifedata.com/resource/pubmed/chemical/Phosphodiesterase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Phospholipases, http://linkedlifedata.com/resource/pubmed/chemical/Piperazines, http://linkedlifedata.com/resource/pubmed/chemical/Purines, http://linkedlifedata.com/resource/pubmed/chemical/Purinones, http://linkedlifedata.com/resource/pubmed/chemical/Sulfones, http://linkedlifedata.com/resource/pubmed/chemical/Testosterone, http://linkedlifedata.com/resource/pubmed/chemical/sildenafil, http://linkedlifedata.com/resource/pubmed/chemical/zaprinast
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
21
pubmed:volume
462
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
155-60
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:12591108-Amrinone, pubmed-meshheading:12591108-Animals, pubmed-meshheading:12591108-Body Weight, pubmed-meshheading:12591108-Calcium, pubmed-meshheading:12591108-Creatinine, pubmed-meshheading:12591108-Dose-Response Relationship, Drug, pubmed-meshheading:12591108-Electric Stimulation, pubmed-meshheading:12591108-Isoenzymes, pubmed-meshheading:12591108-Kidney Failure, Chronic, pubmed-meshheading:12591108-Male, pubmed-meshheading:12591108-Muscle Relaxation, pubmed-meshheading:12591108-Nephrectomy, pubmed-meshheading:12591108-Papaverine, pubmed-meshheading:12591108-Parathyroid Hormone, pubmed-meshheading:12591108-Penis, pubmed-meshheading:12591108-Phosphates, pubmed-meshheading:12591108-Phosphodiesterase Inhibitors, pubmed-meshheading:12591108-Phospholipases, pubmed-meshheading:12591108-Piperazines, pubmed-meshheading:12591108-Purines, pubmed-meshheading:12591108-Purinones, pubmed-meshheading:12591108-Rabbits, pubmed-meshheading:12591108-Sulfones, pubmed-meshheading:12591108-Testosterone
pubmed:year
2003
pubmed:articleTitle
The effect of chronic renal failure on phosphodiesterase inhibitor-induced relaxation responses in rabbit cavernosal strips.
pubmed:affiliation
Department of Urology, Faculty of Medicine, University of Cumhuriyet, 58140 Sivas, Turkey.
pubmed:publicationType
Journal Article, In Vitro