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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2003-2-17
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pubmed:abstractText |
Up-regulation of epithelial vascular endothelial growth factor (VEGF) expression was recently reported at an early stage of bladder carcinogenesis in rats. Subsequently, clotrimazole (CLT) was reported to exert an inhibitory effect on the in vitro proliferation of vascular endothelial cells stimulated by VEGF. The present study was performed to evaluate the effect of CLT on the initial stage of N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN)-induced carcinogenesis of the urinary bladder in rats.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0919-8172
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
78-85
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12588602-Animals,
pubmed-meshheading:12588602-Base Sequence,
pubmed-meshheading:12588602-Butylhydroxybutylnitrosamine,
pubmed-meshheading:12588602-Cell Division,
pubmed-meshheading:12588602-Clotrimazole,
pubmed-meshheading:12588602-Disease Models, Animal,
pubmed-meshheading:12588602-Endothelial Growth Factors,
pubmed-meshheading:12588602-Epithelium,
pubmed-meshheading:12588602-Female,
pubmed-meshheading:12588602-Immunohistochemistry,
pubmed-meshheading:12588602-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:12588602-Lymphokines,
pubmed-meshheading:12588602-Molecular Sequence Data,
pubmed-meshheading:12588602-Neovascularization, Pathologic,
pubmed-meshheading:12588602-Probability,
pubmed-meshheading:12588602-Random Allocation,
pubmed-meshheading:12588602-Rats,
pubmed-meshheading:12588602-Rats, Wistar,
pubmed-meshheading:12588602-Reference Values,
pubmed-meshheading:12588602-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:12588602-Sensitivity and Specificity,
pubmed-meshheading:12588602-Urinary Bladder Neoplasms,
pubmed-meshheading:12588602-Vascular Endothelial Growth Factor A,
pubmed-meshheading:12588602-Vascular Endothelial Growth Factor Receptor-1,
pubmed-meshheading:12588602-Vascular Endothelial Growth Factors
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pubmed:year |
2003
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pubmed:articleTitle |
Inhibitory effect of clotrimazole on angiogenesis associated with bladder epithelium proliferation in rats.
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pubmed:affiliation |
Division of Urology, Saiseikai Matsuyama Hospital, Ehime, Japan. takei@matsuyama.saiseikai.or.jp
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pubmed:publicationType |
Journal Article,
Comparative Study
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