Source:http://linkedlifedata.com/resource/pubmed/id/12582008
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2003-5-8
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| pubmed:abstractText |
High concentrations of nonesterified fatty acids (NEFA) are a risk factor for developing type 2 diabetes in Pima Indians. In vitro and in vivo, chronic elevation of NEFA decreases glucose-stimulated insulin secretion. We hypothesized that high fasting plasma NEFA would increase the risk of type 2 diabetes by inducing a worsening of glucose-stimulated insulin secretion in Pima Indians. To test this hypothesis, fasting plasma NEFA concentrations, body composition, insulin action (M), acute insulin response (AIR, 25-g IVGTT), and glucose tolerance (75-g OGTT) were measured in 151 Pima Indians [107 normal glucose tolerant (NGT), 44 impaired glucose tolerant (IGT)] at the initial visit. These subjects, participants in ongoing studies of the pathogenesis of obesity and type 2 diabetes, had follow-up measurements of body composition, glucose tolerance, M, and AIR. In NGT individuals, cross-sectionally, high fasting plasma NEFA concentrations at the initial visit were negatively associated with AIR after adjustment for age, sex, percent body fat, and M (P = 0.03). Longitudinally, high fasting plasma NEFA concentrations at the initial visit were not associated with change in AIR. In individuals with IGT, cross-sectionally, high fasting plasma NEFA concentrations at the initial visit were not associated with AIR. Longitudinally, high fasting plasma NEFA concentrations at the initial visit were associated with a decrease in AIR before (P < 0.0001) and after adjustment for sex, age at follow-up, time of follow-up, change in percent body fat and insulin sensitivity, and AIR at the initial visit (P = 0.0006). In conclusion, findings in people with NGT indicate that fasting plasma NEFA concentrations are not a primary etiologic factor for beta-cell failure. However, in subjects who have progressed to a state of IGT, chronically elevated NEFA seem to have a deleterious effect on insulin-secretory capacity.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
0193-1849
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
284
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
E1156-61
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12582008-Adolescent,
pubmed-meshheading:12582008-Adult,
pubmed-meshheading:12582008-Body Composition,
pubmed-meshheading:12582008-Body Weight,
pubmed-meshheading:12582008-Cross-Sectional Studies,
pubmed-meshheading:12582008-Diabetes Mellitus,
pubmed-meshheading:12582008-Diabetes Mellitus, Type 2,
pubmed-meshheading:12582008-Fatty Acids, Nonesterified,
pubmed-meshheading:12582008-Female,
pubmed-meshheading:12582008-Glucose Clamp Technique,
pubmed-meshheading:12582008-Glucose Intolerance,
pubmed-meshheading:12582008-Glucose Tolerance Test,
pubmed-meshheading:12582008-Humans,
pubmed-meshheading:12582008-Indians, North American,
pubmed-meshheading:12582008-Insulin Resistance,
pubmed-meshheading:12582008-Linear Models,
pubmed-meshheading:12582008-Longitudinal Studies,
pubmed-meshheading:12582008-Male,
pubmed-meshheading:12582008-Middle Aged,
pubmed-meshheading:12582008-Obesity
|
| pubmed:year |
2003
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| pubmed:articleTitle |
Elevated plasma nonesterified fatty acids are associated with deterioration of acute insulin response in IGT but not NGT.
|
| pubmed:affiliation |
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA. nstefan@mail.nih.gov
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| pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
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