rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
1-2
|
pubmed:dateCreated |
2003-2-10
|
pubmed:abstractText |
Humoral auto-immunity to the myelin oligodendrocyte glycoprotein (MOG) is likely involved in the pathogenesis of multiple sclerosis (MS). In 44 MS patients and 30 controls, Ig-producing B cells were identified by their isotype and as MOG-specific spot-forming cells (SFC). Peripheral anti-MOG antibodies were assayed in ELISA as well as anti-butyrophilin antibodies to investigate for molecular mimicry. MS patients had significantly higher levels of IgA- and MOG-SFC than controls, as well as significantly higher antibody responses to MOG and butyrophilin. These data provide added support for the implication of anti-MOG humoral immunity in the pathophysiology of MS, and suggest a balance of systemic (anti-self) and mucosal (environment-modulated) immune reactions in an attempt at regulating the pathogenic specific immune response.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
0165-5728
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pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
135
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
117-25
|
pubmed:dateRevised |
2011-11-17
|
pubmed:meshHeading |
pubmed-meshheading:12576231-Adult,
pubmed-meshheading:12576231-Aged,
pubmed-meshheading:12576231-Aged, 80 and over,
pubmed-meshheading:12576231-Antibody-Producing Cells,
pubmed-meshheading:12576231-B-Lymphocytes,
pubmed-meshheading:12576231-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:12576231-Female,
pubmed-meshheading:12576231-Flow Cytometry,
pubmed-meshheading:12576231-Humans,
pubmed-meshheading:12576231-Immunoglobulin Isotypes,
pubmed-meshheading:12576231-Male,
pubmed-meshheading:12576231-Membrane Glycoproteins,
pubmed-meshheading:12576231-Middle Aged,
pubmed-meshheading:12576231-Multiple Sclerosis,
pubmed-meshheading:12576231-Myelin Proteins,
pubmed-meshheading:12576231-Myelin-Associated Glycoprotein,
pubmed-meshheading:12576231-Peptide Fragments,
pubmed-meshheading:12576231-Transforming Growth Factor beta
|
pubmed:year |
2003
|
pubmed:articleTitle |
Anti-myelin oligodendrocyte glycoprotein B-cell responses in multiple sclerosis.
|
pubmed:affiliation |
Laboratoire d'Immunologie du CHU, Faculté de Médecine, BP 184, 54500 Vandoeuvre les, 54000, Nancy, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|