Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2003-2-10
pubmed:abstractText
Humoral auto-immunity to the myelin oligodendrocyte glycoprotein (MOG) is likely involved in the pathogenesis of multiple sclerosis (MS). In 44 MS patients and 30 controls, Ig-producing B cells were identified by their isotype and as MOG-specific spot-forming cells (SFC). Peripheral anti-MOG antibodies were assayed in ELISA as well as anti-butyrophilin antibodies to investigate for molecular mimicry. MS patients had significantly higher levels of IgA- and MOG-SFC than controls, as well as significantly higher antibody responses to MOG and butyrophilin. These data provide added support for the implication of anti-MOG humoral immunity in the pathophysiology of MS, and suggest a balance of systemic (anti-self) and mucosal (environment-modulated) immune reactions in an attempt at regulating the pathogenic specific immune response.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0165-5728
pubmed:author
pubmed:issnType
Print
pubmed:volume
135
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
117-25
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:12576231-Adult, pubmed-meshheading:12576231-Aged, pubmed-meshheading:12576231-Aged, 80 and over, pubmed-meshheading:12576231-Antibody-Producing Cells, pubmed-meshheading:12576231-B-Lymphocytes, pubmed-meshheading:12576231-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:12576231-Female, pubmed-meshheading:12576231-Flow Cytometry, pubmed-meshheading:12576231-Humans, pubmed-meshheading:12576231-Immunoglobulin Isotypes, pubmed-meshheading:12576231-Male, pubmed-meshheading:12576231-Membrane Glycoproteins, pubmed-meshheading:12576231-Middle Aged, pubmed-meshheading:12576231-Multiple Sclerosis, pubmed-meshheading:12576231-Myelin Proteins, pubmed-meshheading:12576231-Myelin-Associated Glycoprotein, pubmed-meshheading:12576231-Peptide Fragments, pubmed-meshheading:12576231-Transforming Growth Factor beta
pubmed:year
2003
pubmed:articleTitle
Anti-myelin oligodendrocyte glycoprotein B-cell responses in multiple sclerosis.
pubmed:affiliation
Laboratoire d'Immunologie du CHU, Faculté de Médecine, BP 184, 54500 Vandoeuvre les, 54000, Nancy, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't