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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2003-2-4
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pubmed:abstractText |
Prevention of beta-amyloid (Abeta) production, aggregation and formation of Abeta deposits is a key pharmacological target in Alzheimer's disease. The passage of Abeta-binding compounds through the blood-brain barrier is often hampered for free ligands, whereas it is enhanced by drug encapsulation in nanoparticles. Here, we describe the preparation and characterization of polymeric carriers containing thioflavin-T as a marker for fibrillar Abeta. This study is then focused on electron microscopic analyses of thioflavin-T after injection of thioflavin-T-containing nanoparticles into the mouse hippocampus. Therefore, the photoconversion of fluorescent thioflavin-T as model drug was performed in tissues fixed 3 days post-injection. Thioflavin-T delivered from nanospheres was predominantly found in neurons and microglia. Our data suggest that drugs delivered by nanoparticles might target Abeta in the brain.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
338
|
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
174-6
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:12566180-Alzheimer Disease,
pubmed-meshheading:12566180-Amyloid beta-Peptides,
pubmed-meshheading:12566180-Animals,
pubmed-meshheading:12566180-Drug Carriers,
pubmed-meshheading:12566180-Drug Delivery Systems,
pubmed-meshheading:12566180-Enbucrilate,
pubmed-meshheading:12566180-Female,
pubmed-meshheading:12566180-Fluorescent Dyes,
pubmed-meshheading:12566180-Hippocampus,
pubmed-meshheading:12566180-Injections,
pubmed-meshheading:12566180-Male,
pubmed-meshheading:12566180-Mice,
pubmed-meshheading:12566180-Mice, Inbred C57BL,
pubmed-meshheading:12566180-Microscopy, Electron,
pubmed-meshheading:12566180-Nanotechnology,
pubmed-meshheading:12566180-Particle Size,
pubmed-meshheading:12566180-Polymers,
pubmed-meshheading:12566180-Polystyrenes,
pubmed-meshheading:12566180-Thiazoles
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pubmed:year |
2003
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pubmed:articleTitle |
Electron microscopic analysis of nanoparticles delivering thioflavin-T after intrahippocampal injection in mouse: implications for targeting beta-amyloid in Alzheimer's disease.
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pubmed:affiliation |
Department of Neurochemistry, Paul Flechsig Institute for Brain Research, University of Leipzig, Jahnallee 59, 04109, Leipzig, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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