rdf:type |
|
lifeskim:mentions |
umls-concept:C0008633,
umls-concept:C0017262,
umls-concept:C0031678,
umls-concept:C0080055,
umls-concept:C0086418,
umls-concept:C0168424,
umls-concept:C0185117,
umls-concept:C0237881,
umls-concept:C0694888,
umls-concept:C0750502,
umls-concept:C1334043,
umls-concept:C1553877,
umls-concept:C1608885,
umls-concept:C1880274,
umls-concept:C2239176,
umls-concept:C2697616,
umls-concept:C2911684
|
pubmed:issue |
1
|
pubmed:dateCreated |
2003-2-3
|
pubmed:abstractText |
Tumor suppressor gene phosphatase and tensin homology deleted on chromosome ten (PTEN) was first reported in 1997 and has become a hot spot shortly after discovery. Mutations of PTEN gene in human hepatocellular carcinomas (HCCs) have been examined by several groups abroad, while little is known about expression of PTEN in HCCs. It has been believed that p53 mutation plays a role in the oncogenesis of HCCs. However, divergence exist as regards the relationship between p53 mutation and some biological behaviors of HCCs. The current study was designed to investigate the correlations of expression of PTEN and mutant p53 with carcinogenesis and tumor progression of HCCs.
|
pubmed:language |
chi
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
1000-467X
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
22
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
42-5
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:12561434-Carcinoma, Hepatocellular,
pubmed-meshheading:12561434-Genes, Tumor Suppressor,
pubmed-meshheading:12561434-Genes, p53,
pubmed-meshheading:12561434-Humans,
pubmed-meshheading:12561434-Liver,
pubmed-meshheading:12561434-Liver Neoplasms,
pubmed-meshheading:12561434-Mutation,
pubmed-meshheading:12561434-Neoplasm Invasiveness,
pubmed-meshheading:12561434-PTEN Phosphohydrolase,
pubmed-meshheading:12561434-Phosphoric Monoester Hydrolases,
pubmed-meshheading:12561434-Tumor Suppressor Protein p53,
pubmed-meshheading:12561434-Tumor Suppressor Proteins
|
pubmed:year |
2003
|
pubmed:articleTitle |
[Expression of phosphatase and tensin homology deleted on chromosome ten(PTEN) and p53 protein and their significance in human hepatocellular carcinomas].
|
pubmed:affiliation |
Clinical Laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, P. R. China. chengliming2002@hotmail.com
|
pubmed:publicationType |
Journal Article,
English Abstract
|