12560485

Source:http://linkedlifedata.com/resource/pubmed/id/12560485

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0012933, umls-concept:C0034865, umls-concept:C0036025, umls-concept:C0173022, umls-concept:C1167117
pubmed:issue	3
pubmed:dateCreated	2003-1-31
pubmed:abstractText	In the ribosomal DNA (rDNA) of Saccharomyces cerevisiae replication forks progressing against transcription stall at a polar replication fork barrier (RFB) located close to and downstream of the 35S transcription unit. Forks blocked at this barrier are potentially recombinogenic. Plasmids bearing the RFB sequence in its active orientation integrated into the chromosomal rDNA in sir2 mutant cells but not in wild-type cells, indicating that the histone deacetylase silencing protein Sir2 (Sir2p), which also modulates the aging process in yeast, suppresses the recombination competence of forks blocked at the rDNA RFB. Orientation of the RFB sequence in its inactive course or its abolition by FOB1 deletion avoided plasmid integration in sir2 mutant cells, indicating that stalling of the forks in the plasmid context was required for recombination to take place. Altogether these results strongly suggest that one of the functions of Sir2p is to modulate access of the recombination machinery to the forks stalled at the rDNA RFB.
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0411011
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/DNA, Fungal, http://linkedlifedata.com/resource/pubmed/chemical/DNA, Ribosomal, http://linkedlifedata.com/resource/pubmed/chemical/Histone Deacetylases, http://linkedlifedata.com/resource/pubmed/chemical/SIR2 protein, S cerevisiae, http://linkedlifedata.com/resource/pubmed/chemical/Silent Information Regulator..., http://linkedlifedata.com/resource/pubmed/chemical/Sirtuin 2, http://linkedlifedata.com/resource/pubmed/chemical/Sirtuins
pubmed:status	MEDLINE
pubmed:month	Feb
pubmed:issn	1362-4962
pubmed:author	pubmed-author:BenguríaAlbertoA, pubmed-author:HernándezPabloP, pubmed-author:KrimerDora BDB, pubmed-author:SchvartzmanJorge BJB
pubmed:issnType	Electronic
pubmed:day	1
pubmed:volume	31
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	893-8
pubmed:dateRevised	2009-11-19
pubmed:meshHeading	pubmed-meshheading:12560485-Chromosomes, Fungal, pubmed-meshheading:12560485-DNA, Fungal, pubmed-meshheading:12560485-DNA, Ribosomal, pubmed-meshheading:12560485-DNA Replication, pubmed-meshheading:12560485-Histone Deacetylases, pubmed-meshheading:12560485-Plasmids, pubmed-meshheading:12560485-Recombination, Genetic, pubmed-meshheading:12560485-Saccharomyces cerevisiae, pubmed-meshheading:12560485-Silent Information Regulator Proteins, Saccharomyces..., pubmed-meshheading:12560485-Sirtuin 2, pubmed-meshheading:12560485-Sirtuins
pubmed:year	2003
pubmed:articleTitle	Sir2p suppresses recombination of replication forks stalled at the replication fork barrier of ribosomal DNA in Saccharomyces cerevisiae.
pubmed:affiliation	Departamento de Biología Celular y del Desarrollo, Centro de Investigaciones Biológicas (CSIC), Velázquez 144, 28006 Madrid, Spain.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't