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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9354
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pubmed:dateCreated |
2003-1-31
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pubmed:abstractText |
ATP-sensitive potassium (KATP) channels are major regulators of glucose-induced insulin secretion in pancreatic beta cells. We have described a dominant heterozygous mutation--E1506K--in the sulfonylurea receptor 1 (SUR1) gene (ABCC8) in a Finnish family, which leads to congenital hyperinsulinaemia due to reduction of K(ATP)-channel activity. We aimed to characterise glucose metabolism in adults heterozygous for the E1506K mutation.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0140-6736
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
25
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pubmed:volume |
361
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
301-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12559865-Adult,
pubmed-meshheading:12559865-Diabetes Mellitus, Type 2,
pubmed-meshheading:12559865-Female,
pubmed-meshheading:12559865-Finland,
pubmed-meshheading:12559865-Genotype,
pubmed-meshheading:12559865-Glucose Tolerance Test,
pubmed-meshheading:12559865-Glycosyltransferases,
pubmed-meshheading:12559865-Humans,
pubmed-meshheading:12559865-Hyperinsulinism,
pubmed-meshheading:12559865-Male,
pubmed-meshheading:12559865-Membrane Proteins,
pubmed-meshheading:12559865-Middle Aged,
pubmed-meshheading:12559865-Mutation,
pubmed-meshheading:12559865-Pedigree,
pubmed-meshheading:12559865-Repressor Proteins,
pubmed-meshheading:12559865-Saccharomyces cerevisiae Proteins
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pubmed:year |
2003
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pubmed:articleTitle |
A new subtype of autosomal dominant diabetes attributable to a mutation in the gene for sulfonylurea receptor 1.
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pubmed:affiliation |
Department of Paediatrics, University of Kuopio, Kuopio, Finland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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