Linked Life Data

12555165

Source:http://linkedlifedata.com/resource/pubmed/id/12555165

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6 Suppl
pubmed:dateCreated
2003-1-29
pubmed:abstractText
The mechanical left ventricular assist device (LVAD) has become a reliable means of stabilizing the conditions of medically refractory patients with severe heart failure who are awaiting heart transplantation. At the same time, a substantial and growing body of evidence indicates that LVAD support triggers a multitude of adaptations within the failing human heart that seem to be triggered by hemodynamic unloading of the failing heart and changes in intracardiac and systemic neurohumoral activity. At the cell and tissue level, virtually every type of pathologic defect associated with failing human hearts demonstrates changes during LVAD support, and these adaptations are usually towards a less pathologic phenotype. This review summarizes the available literature concerning the phenomenology of so-called reverse remodeling. From this review it is clear that myocardial responses to LVAD support reveal the remarkable plasticity of even the most severely failing hearts. The composite literature on myocardial responses to LVAD support supports the thesis that mechanical overload is a primary factor sustaining the pathologic phenotype of the failing heart and suggests that the study of reverse remodeling provides a valuable opportunity to discover adaptive signaling pathways capable of mediating myocardial recovery.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1071-9164
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S500-5
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Reversal mechanisms of left ventricular remodeling: lessons from left ventricular assist device experiments.
pubmed:affiliation
Cardiovascular Research Group, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't