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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2003-1-28
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pubmed:abstractText |
To determine the association between genital tract shedding of human immunodeficiency virus (HIV) type 1 and vertical transmission, a case-control substudy was conducted within the Women and Infants Transmission Study. Antenatal cervicovaginal lavage specimens were assessed for HIV-1 RNA in the supernatant and HIV-1 RNA and DNA in cell pellets. Multivariate analyses compared 26 women who transmitted HIV to their infants with 52 women who did not; 33% received combination antiretroviral therapy, and 65% received monotherapy. Adjusted odds ratios (ORs) for the presence (OR, 3.42; 95% confidence interval [CI], 0.76-15.4; P=.11) and titer (OR, 1.66; 95% CI, 0.93-2.99; P=.09) of HIV-1 DNA suggested that there is an independent association with vertical transmission. When analyses were restricted to vaginal and nonelective cesarean deliveries, each one-log increase in mean titer of HIV-1 DNA was associated with a significantly higher risk of transmission (OR, 2.28; 95% CI, 1.09-4.78; P=.03). The cell-associated genital tract compartment is important in the pathophysiology and prevention of vertical HIV-1 transmission.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/1 U01 AI 50274,
http://linkedlifedata.com/resource/pubmed/grant/9U01 DA15054,
http://linkedlifedata.com/resource/pubmed/grant/AI 39042,
http://linkedlifedata.com/resource/pubmed/grant/HD-36117,
http://linkedlifedata.com/resource/pubmed/grant/N01 AI 85339,
http://linkedlifedata.com/resource/pubmed/grant/RR00188,
http://linkedlifedata.com/resource/pubmed/grant/RR00645,
http://linkedlifedata.com/resource/pubmed/grant/U01 AI 34841,
http://linkedlifedata.com/resource/pubmed/grant/U01 AI 34858,
http://linkedlifedata.com/resource/pubmed/grant/U01 DA 15053,
http://linkedlifedata.com/resource/pubmed/grant/U01 HD 41983
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-1899
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pubmed:author |
pubmed-author:AndersonDeborah JDJ,
pubmed-author:BlattnerWilliamW,
pubmed-author:BremerJames WJW,
pubmed-author:CharuratManhattanM,
pubmed-author:JenningsCherylC,
pubmed-author:LandayAlanA,
pubmed-author:MatzenElaineE,
pubmed-author:O'DriscollPeter TPT,
pubmed-author:ReadJennifer SJS,
pubmed-author:TuomalaRuth ERE,
pubmed-author:Women and Infants Transmission Study,
pubmed-author:XuChongC,
pubmed-author:ZorrillaCarmenC
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
187
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
375-84
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12552421-Anti-HIV Agents,
pubmed-meshheading:12552421-Case-Control Studies,
pubmed-meshheading:12552421-Cervix Uteri,
pubmed-meshheading:12552421-DNA, Viral,
pubmed-meshheading:12552421-Female,
pubmed-meshheading:12552421-Genitalia, Female,
pubmed-meshheading:12552421-HIV Infections,
pubmed-meshheading:12552421-HIV-1,
pubmed-meshheading:12552421-Humans,
pubmed-meshheading:12552421-Infant, Newborn,
pubmed-meshheading:12552421-Infectious Disease Transmission, Vertical,
pubmed-meshheading:12552421-Odds Ratio,
pubmed-meshheading:12552421-Pregnancy,
pubmed-meshheading:12552421-Pregnancy Complications, Infectious,
pubmed-meshheading:12552421-RNA, Viral,
pubmed-meshheading:12552421-Risk Factors,
pubmed-meshheading:12552421-Vagina,
pubmed-meshheading:12552421-Virus Shedding
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pubmed:year |
2003
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pubmed:articleTitle |
Cell-associated genital tract virus and vertical transmission of human immunodeficiency virus type 1 in antiretroviral-experienced women.
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pubmed:affiliation |
Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. rtuomala@partners.org
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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