rdf:type |
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lifeskim:mentions |
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pubmed:issue |
Pt 1
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pubmed:dateCreated |
2003-1-27
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pubmed:abstractText |
Mammalian AMP-activated protein kinase presents strong structural and functional similarities with the yeast sucrose non-fermenting 1 (Snf1) kinase involved in the derepression of glucose-repressed genes. It is now clearly established that AMP-activated protein kinase in the liver decreases glycolytic/lipogenic gene expression as well as genes involved in hepatic glucose production. This is achieved through a decreased transcriptional efficiency of transcription factors such as sterol-regulatory-element-binding protein-1c, carbohydrate-response-element-binding protein, hepatocyte nuclear factor 4 alpha or forkhead-related protein. Clearly, the long-term consequences of AMP-activated protein kinase activation have to be taken into account if activators of this enzyme are to be designed as anti-diabetic drugs.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0300-5127
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
220-3
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12546689-AMP-Activated Protein Kinases,
pubmed-meshheading:12546689-Animals,
pubmed-meshheading:12546689-Enzyme Activation,
pubmed-meshheading:12546689-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:12546689-Glucose,
pubmed-meshheading:12546689-Humans,
pubmed-meshheading:12546689-Liver,
pubmed-meshheading:12546689-Multienzyme Complexes,
pubmed-meshheading:12546689-Protein-Serine-Threonine Kinases,
pubmed-meshheading:12546689-RNA, Messenger,
pubmed-meshheading:12546689-Transcription, Genetic
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pubmed:year |
2003
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pubmed:articleTitle |
AMP-activated protein kinase and hepatic genes involved in glucose metabolism.
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pubmed:affiliation |
INSERM Unit 465, Centre de Recherches Biomédicales des Cordeliers, 15, rue de l'Ecole de Médecine, 75270 Paris Cedex 06, France. pferre@bhdc.jussieu.fr
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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