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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2003-1-24
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pubmed:abstractText |
Bone morphogenetic proteins (BMPs) exert cell type-specific effects on cell proliferation. To clarify the role of the BMP pathway in human breast cancer cells, we used a dominant negative strategy with a truncated human type II BMP receptor (DN-BMPRII; amino acid 1-172) fused to the NH2 terminus of enhanced green fluorescent protein. Transient overexpression of DN-BMPRII interfered with BMP-2-induced Smad1 transcriptional activity and caused cells to accumulate in G1. Stable cell lines that constitutively overexpressed DN-BMPRII were resistant to BMP-2-induced Smad1 phosphorylation and proliferated much more slowly than control stable cell lines. These results suggest that BMPs interacting with type II BMP receptors contribute to the proliferation and/or survival of human breast cancer cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/BMP2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/BMPR2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Protein 2,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/SMAD1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Smad Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Smad1 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0008-5472
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
277-81
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12543773-Bone Morphogenetic Protein 2,
pubmed-meshheading:12543773-Bone Morphogenetic Protein Receptors, Type II,
pubmed-meshheading:12543773-Bone Morphogenetic Proteins,
pubmed-meshheading:12543773-Breast Neoplasms,
pubmed-meshheading:12543773-Cell Cycle,
pubmed-meshheading:12543773-Cell Division,
pubmed-meshheading:12543773-DNA-Binding Proteins,
pubmed-meshheading:12543773-Growth Inhibitors,
pubmed-meshheading:12543773-Humans,
pubmed-meshheading:12543773-Phosphorylation,
pubmed-meshheading:12543773-Protein-Serine-Threonine Kinases,
pubmed-meshheading:12543773-Smad Proteins,
pubmed-meshheading:12543773-Smad1 Protein,
pubmed-meshheading:12543773-Trans-Activators,
pubmed-meshheading:12543773-Transfection,
pubmed-meshheading:12543773-Transforming Growth Factor beta,
pubmed-meshheading:12543773-Tumor Cells, Cultured
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pubmed:year |
2003
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pubmed:articleTitle |
Overexpression of a dominant negative type II bone morphogenetic protein receptor inhibits the growth of human breast cancer cells.
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pubmed:affiliation |
Oncology and Molecular Endocrinology Research Center, Centre Hospitalier de l'Université Loval Research Center Centre Hospitalier Universitaire de Quebec and Laval University, Sainte-Foy, Quebec, G1V 4G2 Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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