Linked Life Data

12541097

Source:http://linkedlifedata.com/resource/pubmed/id/12541097

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2003-1-23
pubmed:abstractText
Nitroglycerin-mediated vasorelaxation is chiefly attributed to the cyclic guanosine monophosphate (cGMP)-dependent pathway, and partly to the cGMP-independent pathway via calcium-activated K(+) channels (K(Ca)). To investigate whether chronic hypertension alters responses of vascular smooth muscle to vasoactive agonists, we determined nitroglycerin-mediated relaxation of aortic rings from coarctation hypertensive rats. Banding the abdominal aorta above the renal arteries for 4 weeks elevated blood pressure and caused cardiac hypertrophy by 49%. In response to nitroglycerin, the relaxation of aortic rings precontracted with 10(-7) M norepinephrine was lower in the banded group than in the sham-operated group. Methylene blue, a guanylate cyclase inhibitor, suppressed a greater part of nitroglycerin-mediated relaxation and reached similar levels of relaxation in the two groups. Charybdotoxin, a specific K(Ca) channel blocker, also suppressed the relaxation by about 40% in the aortic rings from sham-operated animals, but not in those from the banded group. The response to charybdotoxin was markedly diminished or virtually eliminated in the banded group in the presence or absence of methylene blue. The combination of charybdotoxin and methylene blue nearly abolished nitroglycerin-mediated relaxation in the sham-operated group, whereas nitroglycerin-mediated relaxation was seen to remain in the banded group. These results indicate that the involvement of cGMP-independent K(Ca) channels in nitroglycerin-mediated relaxation disappeared after the development of hypertension produced by aortic coarctation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0910-8327
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
69-73
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:12541097-Animals, pubmed-meshheading:12541097-Aorta, Abdominal, pubmed-meshheading:12541097-Aorta, Thoracic, pubmed-meshheading:12541097-Aortic Coarctation, pubmed-meshheading:12541097-Blood Pressure, pubmed-meshheading:12541097-Charybdotoxin, pubmed-meshheading:12541097-Disease Models, Animal, pubmed-meshheading:12541097-Dose-Response Relationship, Drug, pubmed-meshheading:12541097-Drug Combinations, pubmed-meshheading:12541097-Heart Rate, pubmed-meshheading:12541097-Hydrocarbons, pubmed-meshheading:12541097-Hypertension, pubmed-meshheading:12541097-Male, pubmed-meshheading:12541097-Methane, pubmed-meshheading:12541097-Models, Cardiovascular, pubmed-meshheading:12541097-Muscle, Smooth, Vascular, pubmed-meshheading:12541097-Nitroglycerin, pubmed-meshheading:12541097-Norepinephrine, pubmed-meshheading:12541097-Rats, pubmed-meshheading:12541097-Rats, Wistar, pubmed-meshheading:12541097-Systole, pubmed-meshheading:12541097-Time Factors, pubmed-meshheading:12541097-Vasoconstriction, pubmed-meshheading:12541097-Vasoconstrictor Agents, pubmed-meshheading:12541097-Vasodilation, pubmed-meshheading:12541097-Vasodilator Agents
pubmed:year
2002
pubmed:articleTitle
Relaxant properties mediated by nitroglycerin in aortic coarctation hypertensive rats.
pubmed:affiliation
Internal Medicine II, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
pubmed:publicationType
Journal Article, Comparative Study, Evaluation Studies