Source:http://linkedlifedata.com/resource/pubmed/id/12540375
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2003-4-4
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| pubmed:abstractText |
We examined the long-term effect of in utero exposure to streptozotocin-induced maternal diabetes on the progeny that postnatally received either ad libitum access to milk by being fed by control mothers (CM/DP) or were subjected to relative nutrient restriction by being fed by diabetic mothers (DM/DP) compared with the control progeny fed by control mothers (CM/CP). There was increased food intake, glucose intolerance, and obesity in the CM/DP group and diminished food intake, glucose tolerance, and postnatal growth restriction in the DM/DP group, persisting in the adult. These changes were associated with aberrations in hormonal and metabolic profiles and alterations in hypothalamic neuropeptide Y concentrations. By use of subfractionation and Western blot analysis techniques, the CM/DP group demonstrated a higher skeletal muscle sarcolemma-associated (days 1 and 60) and white adipose tissue plasma membrane-associated (day 60) GLUT4 in the basal state with a lack of insulin-induced translocation. The DM/DP group demonstrated a partial amelioration of this change observed in the CM/DP group. We conclude that the offspring of a diabetic mother with ad libitum postnatal nutrition demonstrates increased food intake and resistance to insulin-induced translocation of GLUT4 in skeletal muscle and white adipose tissue. This in turn leads to glucose intolerance and obesity at a later stage (day 180). Postnatal nutrient restriction results in reversal of this adult phenotype, thereby explaining the phenotypic heterogeneity that exists in this population.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Glucose Transporter Type 4,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Monosaccharide Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Muscle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Slc2a4 protein, rat
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| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
0193-1849
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
284
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
E901-14
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:12540375-Adipose Tissue,
pubmed-meshheading:12540375-Animals,
pubmed-meshheading:12540375-Animals, Newborn,
pubmed-meshheading:12540375-Biological Transport,
pubmed-meshheading:12540375-Diabetes Mellitus, Experimental,
pubmed-meshheading:12540375-Drinking,
pubmed-meshheading:12540375-Female,
pubmed-meshheading:12540375-Forecasting,
pubmed-meshheading:12540375-Glucose Intolerance,
pubmed-meshheading:12540375-Glucose Transporter Type 4,
pubmed-meshheading:12540375-Growth Disorders,
pubmed-meshheading:12540375-Insulin,
pubmed-meshheading:12540375-Lactation,
pubmed-meshheading:12540375-Monosaccharide Transport Proteins,
pubmed-meshheading:12540375-Muscle, Skeletal,
pubmed-meshheading:12540375-Muscle Proteins,
pubmed-meshheading:12540375-Obesity,
pubmed-meshheading:12540375-Pregnancy,
pubmed-meshheading:12540375-Pregnancy in Diabetics,
pubmed-meshheading:12540375-Rats,
pubmed-meshheading:12540375-Rats, Sprague-Dawley,
pubmed-meshheading:12540375-Sarcolemma
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| pubmed:year |
2003
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| pubmed:articleTitle |
Aberrant insulin-induced GLUT4 translocation predicts glucose intolerance in the offspring of a diabetic mother.
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| pubmed:affiliation |
Division of Neonatology and Developmental Biology, Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1752, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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