|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2003-1-22
|
|
pubmed:abstractText |
T lymphocytes expressing the T cell receptor (TCR)-gammadelta recognize unknown antigens on tumor cells. Here we identify metabolites of the mevalonate pathway as the tumor ligands that activate TCR-gammadelta cells. In tumor cells, blockade of hydroxy-methylglutaryl-CoA reductase (HMGR), the rate limiting enzyme of the mevalonate pathway, prevents both accumulation of mevalonate metabolites and recognition by TCR-gammadelta cells. When metabolite accumulation is induced by overexpressing HMGR or by treatment with nitrogen-containing bisphosphonate drugs, tumor cells derived from many tissues acquire the capacity to stimulate the same TCR-gammadelta population. Accumulation of mevalonate metabolites in tumor cells is a powerful danger signal that activates the immune response and may represent a novel target of tumor immunotherapy.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12538656-10403829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12538656-10542241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12538656-10557091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12538656-10620343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12538656-10782041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12538656-10872447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12538656-10887096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12538656-11116953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12538656-11160603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12538656-11349148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12538656-11520816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12538656-11673519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12538656-11675382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12538656-1352063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12538656-1394184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12538656-1650758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12538656-1707908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12538656-1770307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12538656-1827824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12538656-1967820,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12538656-1978758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12538656-3379053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12538656-7584140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12538656-7621879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12538656-7753173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12538656-8021239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12538656-8146660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12538656-8612233,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12538656-9018970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12538656-9548596
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0022-1007
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
20
|
|
pubmed:volume |
197
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
163-8
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:12538656-Breast Neoplasms,
pubmed-meshheading:12538656-Cells, Cultured,
pubmed-meshheading:12538656-Female,
pubmed-meshheading:12538656-Humans,
pubmed-meshheading:12538656-Hydroxymethylglutaryl CoA Reductases,
pubmed-meshheading:12538656-Immunotherapy,
pubmed-meshheading:12538656-Lymphocyte Activation,
pubmed-meshheading:12538656-Mevalonic Acid,
pubmed-meshheading:12538656-Neoplasms,
pubmed-meshheading:12538656-Phosphorylation,
pubmed-meshheading:12538656-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:12538656-T-Lymphocyte Subsets,
pubmed-meshheading:12538656-Transfection,
pubmed-meshheading:12538656-Tumor Cells, Cultured
|
|
pubmed:year |
2003
|
|
pubmed:articleTitle |
Human T cell receptor gammadelta cells recognize endogenous mevalonate metabolites in tumor cells.
|
|
pubmed:affiliation |
Experimental Immunology, Department of Research, University Hospital, University of Basel, Hebelstrasse 20, CH-4031 Basel, Switzerland.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
