|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2003-1-22
|
|
pubmed:abstractText |
The methanolic extract of the roots of Saussurea lappa CLARKE, a Chinese medicinal herb Saussureae Radix, was found to inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-activated mouse peritoneal macrophages. Among the constituents from the methanolic extract, two sesquiterpene lactones (costunolide and dehydrocostus lactone) and two amino acid-sesquiterpene conjugates (saussureamines A and B) potently inhibited LPS-induced NO production (IC(50)=1.2-2.8 microM). Saussureamines A and B in addition to costunolide and dehydrocostus lactone did not inhibit iNOS enzyme activity, but they inhibited both induction of inducible NO synthase and activation of nuclear factor-kappaB in accordance with induction of heat shock protein 72.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acids,
http://linkedlifedata.com/resource/pubmed/chemical/HSP72 Heat-Shock Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Heat-Shock Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Indicators and Reagents,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Nos2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Sesquiterpenes
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0968-0896
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
6
|
|
pubmed:volume |
11
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
709-15
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:12538000-Algorithms,
pubmed-meshheading:12538000-Amino Acids,
pubmed-meshheading:12538000-Animals,
pubmed-meshheading:12538000-Electrophoretic Mobility Shift Assay,
pubmed-meshheading:12538000-Enzyme Induction,
pubmed-meshheading:12538000-HSP72 Heat-Shock Proteins,
pubmed-meshheading:12538000-Heat-Shock Proteins,
pubmed-meshheading:12538000-Indicators and Reagents,
pubmed-meshheading:12538000-Lipopolysaccharides,
pubmed-meshheading:12538000-Macrophage Activation,
pubmed-meshheading:12538000-Macrophages,
pubmed-meshheading:12538000-Mice,
pubmed-meshheading:12538000-NF-kappa B,
pubmed-meshheading:12538000-Nitric Oxide,
pubmed-meshheading:12538000-Nitric Oxide Synthase,
pubmed-meshheading:12538000-Nitric Oxide Synthase Type II,
pubmed-meshheading:12538000-Plant Roots,
pubmed-meshheading:12538000-Saussurea,
pubmed-meshheading:12538000-Sesquiterpenes,
pubmed-meshheading:12538000-Structure-Activity Relationship
|
|
pubmed:year |
2003
|
|
pubmed:articleTitle |
Effects of sesquiterpenes and amino acid-sesquiterpene conjugates from the roots of Saussurea lappa on inducible nitric oxide synthase and heat shock protein in lipopolysaccharide-activated macrophages.
|
|
pubmed:affiliation |
Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, 607-8412, Kyoto, Japan.
|
|
pubmed:publicationType |
Journal Article,
In Vitro
|
