| pubmed-article:12536074 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12536074 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:12536074 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:12536074 | lifeskim:mentions | umls-concept:C0015127 | lld:lifeskim |
| pubmed-article:12536074 | lifeskim:mentions | umls-concept:C1326205 | lld:lifeskim |
| pubmed-article:12536074 | lifeskim:mentions | umls-concept:C1314792 | lld:lifeskim |
| pubmed-article:12536074 | lifeskim:mentions | umls-concept:C0332325 | lld:lifeskim |
| pubmed-article:12536074 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:12536074 | lifeskim:mentions | umls-concept:C0251991 | lld:lifeskim |
| pubmed-article:12536074 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:12536074 | pubmed:dateCreated | 2003-1-21 | lld:pubmed |
| pubmed-article:12536074 | pubmed:abstractText | Protein kinase B (PKB), a kinase downstream of phosphatidylinositol 3-kinase (PI3-kinase) provides anti-apoptotic and survival signals via phosphorylation of various targets. Inhibiting PI3-kinase with a 12 h exposure to 10 microM LY294002 induces levels of apoptosis of 30.39+/-1.53% in the KB-V1 multidrug resistant (MDR) cell line compared to 4.54+/-1.00% in drug sensitive KB-3-1 cells (P<0.001). This occurred in conjunction with a preferential reduction in activated PKB in MDR cells. These results suggest the PI3-kinase/PKB signalling pathway is important for the survival of MDR cells and inhibition of this pathway results in the selective induction of apoptosis in MDR cells. | lld:pubmed |
| pubmed-article:12536074 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12536074 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12536074 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12536074 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12536074 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12536074 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12536074 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:12536074 | pubmed:issn | 0304-3835 | lld:pubmed |
| pubmed-article:12536074 | pubmed:author | pubmed-author:KellettG LGL | lld:pubmed |
| pubmed-article:12536074 | pubmed:author | pubmed-author:WarrJ RJR | lld:pubmed |
| pubmed-article:12536074 | pubmed:author | pubmed-author:QuinnD MDM | lld:pubmed |
| pubmed-article:12536074 | pubmed:author | pubmed-author:NicholsonK... | lld:pubmed |
| pubmed-article:12536074 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12536074 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:12536074 | pubmed:volume | 190 | lld:pubmed |
| pubmed-article:12536074 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12536074 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12536074 | pubmed:pagination | 31-6 | lld:pubmed |
| pubmed-article:12536074 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:12536074 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12536074 | pubmed:articleTitle | LY294002, an inhibitor of phosphatidylinositol-3-kinase, causes preferential induction of apoptosis in human multidrug resistant cells. | lld:pubmed |
| pubmed-article:12536074 | pubmed:affiliation | Department of Biology, University of York, PO Box 373, York YO10 5YW, UK. | lld:pubmed |
| pubmed-article:12536074 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12536074 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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